ArticleThe journal of allergy and clinical immunology. Global2026
Identification of severe eosinophilic asthma in patients with chronic rhinosinusitis and nasal polyps who are awaiting sinus surgery.
Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common comorbidity within severe asthma populations; its presence is associated with increased severity of disease and eosinophilic inflammation that may require biologic therapies. Objective: We sought to identify potential patients with severe eosinophilic asthma in a population of patients with CRSwNP who were awaiting functional endoscopic sinus surgery (FESS) for nasal polyps. Methods: We conducted a service evaluation of patients with CRSwNP who were awaiting FESS in a district general hospital. We screened electronic records for eosinophil levels, previous asthma diagnosis, symptoms, and medical treatment. Results: Of the 709 patients on the otolaryngology waiting list, 123 patients with CRSwNP were awaiting FESS. Of those patients, 74 had previous eosinophilia (serum eosinophil count ≥ 0.3 x10 Conclusion: We have identified patients with CRSwNP awaiting nasal polyp surgery who have eosinophillic asthma that may benefit from treatment optimization and review in a severe asthma service. Proactive identification of patients with severe asthma and comorbid CRSwNP who are currently awaiting FESS may widen access to asthma optimization and biologic medications.
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