Evidence map›Paper›PMID 42733470›Full record

ArticleiScience2026

Hippuric acid contributes to NK-cell activation with dependence on TLR2 in chronic hepatitis B complicated by MASLD.

Luyuan Zhang, Anqi Li, Ke Xu, Siyang Tao, Meijuan Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luyuan ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Anqi LiDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Ke XuDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Siyang TaoDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Meijuan ZhengDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coexistence of chronic hepatitis B and metabolic dysfunction-associated steatotic liver disease (CHB-MASLD) has been linked to accelerated fibrosis progression and less favorable clinical outcomes, but the immunopathological mechanisms remain incompletely understood. In the present study, we observed that CHB-MASLD patients exhibited significantly increased peripheral natural killer (NK) cell frequency and activation, with transcriptomic analysis revealing enrichment of inflammatory effector gene signatures. Notably, TLR2 was found to be upregulated in NK cells from CHB-MASLD patients and the frequency of TLR2-expressing NK cells correlated with metabolic parameters and liver stiffness.

Indexed as

chronic hepatitis Bhippuric acidMASLDNK cellstoll-like receptor 2

Identifiers

PMID42733470
PMCPMC13571118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.