Evidence map›Paper›PMID 42733466›Full record

ArticleiScience2026

R0 Resection improves survival after multivisceral resection for pancreatic ductal adenocarcinoma.

Artur Rebelo, Bodil Andersson, Samik Kumar Bandyopadhyay, Paulina Bereza-Carlson, Frederik Berrevoet, Bergthor Björnsson, Stefan Bouwense, Erik Bergquist, Florian Bösch, Markus Büchler and 44 more

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Artur RebeloDepartment of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Bodil AnderssonDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Samik Kumar BandyopadhyayManchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
Paulina Bereza-CarlsonDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Frederik BerrevoetDepartment of General and HPB Surgery and Liver Transplantation University Hospital Gent, Gent, Belgium.
Bergthor BjörnssonDepartment of Surgery in Linköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Stefan BouwenseDepartment of Surgery, Maastricht University Medical Centre, Maastricht 6229 HX, the Netherlands.
Erik BergquistDepartment of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Florian BöschDepartment of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen-Weende, Germany.
Markus BüchlerBotton-Champalimaud Pancreatic Cancer Center, Lisbon, Portugal.
Nikolaos ChatzizachariasHPB and Liver Transplant Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Laurent CoubeauDepartment of Abdominal Surgery and Transplantation at Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Marie CredeDepartment of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen-Weende, Germany.
Cristine B Pathirannehalage DonHPB and Liver Transplant Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Pieter DriesDepartment of General and HPB Surgery and Liver Transplantation University Hospital Gent, Gent, Belgium.
Mert ErkanMehmet Ali Aydinlar Acibadem University, Atakent University Hospital, Istanbul 34303, Turkey.
Matthäus FelsensteinDepartment of Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Isabella FrigerioHPB Unit, Peschiera del Garda, Verona, Italy.
Alessandro GiardinoHPB Unit, Peschiera del Garda, Verona, Italy.
Tim GlowkaDepartment of Surgery, Bonn University, Bonn, Germany.
Parsa HadesiDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Vera HartmanAntwerp University Hospital, Department of HPB, Endocrine and Transplantation Surgery, Edegem, Belgium.
Karin JohansenDepartment of Surgery in Linköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Marie KleinDepartment of General, Visceral, Endocrine, and Transplant Surgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
Johannes KloseDepartment of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Karl KnipperDepartment of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Lindenthal, Germany.
Carl-Stephan LeonhardtDepartment of General Surgery, Division of Visceral Surgery, Medical University of Vienna, Wien, Austria.
Martin LoosDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Thomas MalinkaDepartment of Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Giovanni MarchegianiUniversity of Padua, Department of Surgical, Oncological and Gastroenterological Sciences, Padova, Italy.
Christopher MånssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Riccardo PellegriniUniversity of Padua, Department of Surgical, Oncological and Gastroenterological Sciences, Padova, Italy.
Giampaolo PerriUniversity of Padua, Department of Surgical, Oncological and Gastroenterological Sciences, Padova, Italy.
L H PoelslerDepartment of Visceral, Transplant and Thoracic Surgery, Innsbruck, Austria.
Geert RoeyenAntwerp University Hospital, Department of HPB, Endocrine and Transplantation Surgery, Edegem, Belgium.
Michael RousekDepartment of Surgery, Second Faculty of Medicine of Charles University and Military University Hospital, Prague, Czech Republic.
Pablo SanchoHPB Surgical Division, Miguel Servet University Hospital, Zaragoza, Spain.
Stina Schild-SuhrenDepartment of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen-Weende, Germany.
Thomas SchmidtDepartment of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Lindenthal, Germany.
Leyre SerrabloHPB Surgical Division, Miguel Servet University Hospital, Zaragoza, Spain.
Alejandro SerrabloHPB Surgical Division, Miguel Servet University Hospital, Zaragoza, Spain.
Andrew Malvern SmithSt James University Hospital, Leeds, UK.
Gregor A StavrouDepartment of General, Visceral and Thoracic Surgery, Surgical Oncology, Klinikum Saarbruecken, Saarbruecken, Germany.
Oliver StrobelDepartment of General Surgery, Division of Visceral Surgery, Medical University of Vienna, Wien, Austria.
Shailesh ShrikhandeTata Memorial Hospital, Mumbai, India.
Alexandra StrobelInstitute of Medical Epidemiology, Biostatistics, and Informatics, Interdisciplinary Center for Health Sciences, Medical Faculty of Martin Luther University Halle-Wittenberg, Wittenberg, Germany.
Ignazio TarantinoDepartment of General, Visceral, Endocrine, and Transplant Surgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
Jozef UrdzikDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Tim VilzDepartment of Surgery, Bonn University, Bonn, Germany.
Roberta VellaHPB Unit, Peschiera del Garda, Verona, Italy.
Johanna WennerblomDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Patricia WyzlicDepartment of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Lindenthal, Germany.
Jörg KleeffDepartment of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Multivisceral Pancreatic Resections Research Group: A Collaboration of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achieving negative resection margins (R0) is central to curative surgery for pancreatic ductal adenocarcinoma (PDAC), but its prognostic relevance in multivisceral resections has been unclear. Using the largest international registry of multivisceral pancreatic resections, we performed a propensity score-matched analysis comparing R0 and R1 resections in patients undergoing multivisceral resection for PDAC. After 1:1 matching on pre- and intra-operative covariates, 222 patients were analyzed (111 R0, 111 R1). Perioperative morbidity, 90-day mortality, and intraoperative complications were comparable between groups. Median overall survival was 22.3 months after R0 resection versus 14.5 months after R1 resection; R1 status remained independently associated with poorer survival after adjustment for residual imbalances (hazard ratio [HR] 1.45, 95% confidence interval [CI] 1.02-2.07). Margin-negative resection is associated with improved long-term survival in multivisceral pancreatic surgery without an accompanying increase in perioperative risk, supporting R0 resection as a goal of surgical strategy at specialized centers.

Indexed as

multivisceralpancreaticsurgery

Identifiers

PMID42733466
PMCPMC13571119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.