ArticleJournal of oral biology and craniofacial research
Clinical and patient-reported outcomes of microneedling with ascorbic acid versus scalpel technique for gingival depigmentation: A randomized clinical trial.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objectives: To compare gingival depigmentation achieved with microneedling and topical ascorbic acid (MN + AA) versus the conventional scalpel technique, along with evaluation of repigmentation and patient-reported outcomes (PROMs). Gingival thickness (GT) and dermal-gingival pigmentation associations were also explored. Methods: Twenty-six participants with maxillary physiologic gingival hyperpigmentation were randomized (1:1) to scalpel or MN + AA using an automated microneedling pen. Gingival pigmentation was assessed clinically (Dummett-Gupta Oral Pigmentation Index [DOPI], Gingival Pigmentation Index [GPI]); photographically (Pigmented Surface Area [PSA], Lightness [L]), and using a melanin meter (Gingival Melanin Meter Score, GMMS) at baseline, 1, 3, and 6 months. Primary outcome was change in DOPI at 1 month. Gingival Thickness (GT) and Dermal Melanin Meter Scores (DMMS) were recorded. Results: Twenty-three participants completed the study. The scalpel group showed greater reduction in DOPI, GPI, PSA, GMMS, and a greater increase in L at 1 month ( Conclusion: Both treatments significantly reduced gingival pigmentation at 1 month, with the scalpel technique showing lower pigmentation intensity at 6 months. Both treatments were well tolerated with favorable PROMs. Clinical trial registration number: CTRI/2024/05/066602
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