Evidence map›Paper›PMID 42733452›Full record

ArticleiScience2026

Single-cell multi-omic profiling of heterogeneous PROCR

Koon-Kiu Yan, Erin Nekritz, Zhen Xie, Bensheng Ju, Xinran Dong, Rachel Werner, Dayanira Alsina-Beauchamp, Celeste Rosencrance, Partha Mukhopadhyay, Qingfei Pan and 10 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Koon-Kiu YanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Erin NekritzDepartment of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Zhen XieDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bensheng JuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xinran DongDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Rachel WernerDepartment of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Dayanira Alsina-BeauchampDepartment of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Celeste RosencranceDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Partha MukhopadhyayDepartment of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Qingfei PanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Andrej GorbatenkoDepartment of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Honglei ZhouDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lei YanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Liang DingDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chenxi QianDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sivaraman NatarajanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jose SilvaDepartment of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Jiyang YuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Funding

Investigating the Molecular Determinants Driving Response and Resistance to HDAC6 Targeted Therapy in Breast CancerR01CA274251 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jose M Silva, Jiyang Yu · 2024 to 2026
$1.7M
Intracellular and Intercellular Network Rewiring and Hidden Driver Inference from Single-Cell DataR01GM134382 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YU, JIYANG · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA274251NIGMS NIH HHS R01 GM134382
6 · The paper itself

Abstract

Protein C receptor (PROCR) marks a rare population of mammary epithelial cells with stem-like properties, but their low abundance has hindered characterization of their functional diversity and regulatory programs. Here, we integrate targeted enrichment with single-cell transcriptomic and chromatin accessibility profiling to construct a multimodal atlas of PROCR

Indexed as

agingmammary epithelial stem cellProcrscATAC-seqsingle-cell RNA-seqsystems biology

Identifiers

PMID42733452
PMCPMC13571155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.