ArticleCureus2026
Sunitinib-Induced Hand-Foot Skin Reaction: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand-foot skin reaction (HFSR) is a common dermatological adverse effect of multikinase inhibitors like sunitinib that can impair quality of life and disrupt treatment continuity. We report a 52-year-old male with metastatic renal cell carcinoma who developed Common Terminology Criteria for Adverse Events (CTCAE v5.0) Grade 2 sunitinib-induced HFSR presenting as painful palmar-plantar hyperpigmented lesions and bullae during his third treatment cycle (50 mg/day; two weeks on, one week off). Sunitinib was temporarily held, and multimodal supportive management (including topical corticosteroids, analgesics, and skin barrier care) was initiated. Following complete resolution of lesions, sunitinib was safely resumed at a reduced dose of 37.5 mg daily with no recurrence of HFSR, maintaining oncological therapy. This case suggests that temporary drug interruption combined with targeted supportive care and step-down dose rechallenge may serve as a manageable strategy for Grade 2 HFSR in select patients. However, the efficacy and safety of this approach cannot be generalized, and further studies are needed to establish standardized rechallenge protocols.
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Registered trials
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