Evidence map›Paper›PMID 42733370›Full record

ArticleProblemy endokrinologii2026

[Features of Asymptomatic Pheochromocytoma/Paraganglioma Based on Clinical-Laboratory Examination and Computed Tomography].

D V Rebrova, S N Fogt, R A Chernikov, I V Sleptsov, E A Fedorov, I K Chinchuk, Sh Sh Shikhmagomedov, N V Vorokhobina, E A Zgoda, A A Semenov and 2 more

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In one paragraph

Article in Problemy endokrinologii, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

D V RebrovaSaint Petersburg State University, Saint Petersburg State University Hospital.
S N FogtNorth-Western State Medical University named after I.I. Mechnikov.
R A ChernikovSaint Petersburg State University, Saint Petersburg State University Hospital.
I V SleptsovSaint Petersburg State University, Saint Petersburg State University Hospital.
E A FedorovSaint Petersburg State University, Saint Petersburg State University Hospital.
I K ChinchukSaint Petersburg State University, Saint Petersburg State University Hospital.
Sh Sh ShikhmagomedovSaint Petersburg State University, Saint Petersburg State University Hospital.
N V VorokhobinaNorth-Western State Medical University named after I.I. Mechnikov.
E A ZgodaSaint Petersburg State University, Saint Petersburg State University Hospital.
A A SemenovSaint Petersburg State University, Saint Petersburg State University Hospital.
V F RusakovSaint Petersburg State University, Saint Petersburg State University Hospital.
L M KrasnovSaint Petersburg State University, Saint Petersburg State University Hospital.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough pheochromocytomas and paragangliomas (PPGLs) classically present with distinct clinical signs, there is a category of patients with asymptomatic disease course. Despite the absence of clinical manifestations, these patients retain the risk of life-threatening hypertensive crisis and other cardiovascular complications. The clinical, laboratory, and imaging characteristics of asymptomatic PPGLs remain insufficiently studied and are of significant scientific and practical interest.

aimTo analyze the clinical, laboratory, and imaging characteristics of asymptomatic PPGLs compared to symptomatic ones. MATERIALS AND

methodsThe analysis included 347 patients with histologically confirmed PPGL who underwent surgery at the Saint Petersburg State University Hospital. Retrospective analysis encompassed demographic data, medical history (primary and comorbid conditions), laboratory findings, and computed tomography (CT) data.

resultsThe PPGLs patient cohort included 45 cases without clinical signs of catecholamine hypersecretion. The asymptomatic subgroup, compared to symptomatic patients, exhibited younger age (43 [33; 51] vs. 48 [37; 57] years); smaller maximum tumor size (34 [27; 53] vs. 45 [34; 60] mm); lower metanephrine/normetanephrine ratio (0.29 [0.10; 0.79] vs. 0.51 [0.09; 1.23]).CT imaging revealed slightly higher radiodensity values in asymptomatic PPGLs during arterial, venous, and delayed phases compared to symptomatic tumors. However, absolute and relative washout percentages did not differ significantly.

conclusionThe younger age and smaller tumor size in asymptomatic PPGL patients suggest earlier detection of the disease compared to symptomatic cases. The lower metanephrine/normetanephrine ratio may indicate a higher prevalence of the norepinephrine-secreting phenotype in asymptomatic PPGLs. No pronounced differences were found in imaging characteristics between asymptomatic and symptomatic tumors.

Indexed as

Adrenal Gland NeoplasmsParagangliomaPheochromocytomaAdultAsymptomatic DiseasesFemaleHumansMaleMetanephrineMiddle AgedRetrospective StudiesTomography, X-Ray ComputedMetanephrine

Identifiers

PMID42733370
PMCPMC13585295

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