Evidence map›Paper›PMID 42733176›Full record

SynthesisJournal of food science2026

Green Extraction Techniques for Recovering Polyphenols From Cocoa Bean Shells for Application in Food Processing: A Systematic Review.

Joy Chinenye Mba, Leda Atílio Pita, Helen Obioma Agu, Chioke Amaefuna Okolo, Carmen Sílvia Fávaro-Trindade

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joy Chinenye MbaFaculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de São Paulo (USP), Pirassununga, São Paulo, Brazil.
Leda Atílio PitaFaculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de São Paulo (USP), Pirassununga, São Paulo, Brazil.
Helen Obioma AguDepartment of Food Science and Technology, Nnamdi Azikiwe University, Awka, Anambra, Nigeria.
Chioke Amaefuna OkoloDepartment of Food Science and Technology, Nnamdi Azikiwe University, Awka, Anambra, Nigeria.
Carmen Sílvia Fávaro-TrindadeFaculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de São Paulo (USP), Pirassununga, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7642-7631

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

Cocoa bean shells (CBSs), a by-product of cocoa processing, are an underutilized source of bioactive polyphenols with strong potential for functional food applications. Although several studies and reviews have investigated polyphenol extraction techniques, gaps remain in consolidating findings, optimizing extraction conditions, and understanding the synergistic effects of combined green extraction methods under comparable conditions. This systematic review critically evaluates environmentally sustainable approaches for maximizing polyphenol recovery from CBS for food applications. Literature searches were conducted in Web of Science, Scopus, and PubMed, and studies were selected according to the PICOS (population, intervention, comparison, outcomes, and study design) framework and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Thirty-six articles published between 2010 and 2025 across 15 countries were included. The findings showed that green extraction technologies generally demonstrated higher polyphenol recovery, enhanced the stability and antioxidant activity of the recovered polyphenols, reduced extraction time, and lowered solvent consumption under optimized extraction conditions. However, combining green extraction techniques did not significantly increase total phenolic content compared with single-technique approaches, suggesting that process intensification does not always improve extraction efficiency. Considerable variability in reported total phenolic content was observed in the reviewed papers due to differences in extraction conditions, solvent systems, and reporting units. Overall, CBS demonstrated strong potential as a sustainable source of polyphenols, while green extraction technologies provide a promising strategy for valorizing CBS into high-value ingredients for functional foods, nutraceuticals, and natural preservatives.

Indexed as

CacaoFood HandlingGreen Chemistry TechnologyPolyphenolsAntioxidantsPlant ExtractsSeedsAntioxidantsPlant ExtractsPolyphenolsantioxidant activitycocoa bean shellsfood processing applicationsgreen extraction techniquespolyphenolssustainable extractionwaste valorization

Identifiers

PMID42733176
PMCPMC13572784

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.