ArticleDiabetes, obesity & metabolism2026
OGTT-Derived β-Cell Function-Based Stratification of 2-Year Glycaemic Transitions in Chinese Adults With Prediabetes.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- OGTT-Derived β-Cell Function-Based Stratification of 2-Year Glycaemic Transitions in Chinese Adults With Prediabetes.Diabetes, obesity & metabolism · 2026Article
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14 authors.
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Abstract
aimsPrediabetes is heterogeneous, with variable progression to diabetes or reversion to normoglycemia. We evaluated whether the insulin secretion-sensitivity index-2 (ISSI-2), an oral glucose tolerance test (OGTT)-derived integrated surrogate of β-cell function relative to insulin sensitivity and prevailing glycemia, was associated with baseline glycaemic profiles and 2-year transitions in Chinese adults with prediabetes. We also examined whether these associations differed from those of the homeostasis model assessment of insulin resistance (HOMA-IR) and whether cohort-specific index-based groups combining ISSI-2 and HOMA-IR stratified transition risk. MATERIALS AND
methodsWe analysed 645 Chinese adults with prediabetes and complete baseline OGTT glucose and insulin measurements from a multicentre lifestyle intervention cohort; 410 had 2-year outcomes. ISSI-2 and HOMA-IR were examined in relation to baseline glycaemic measures and 2-year progression or reversion using multivariable regression.
resultsHigher ISSI-2 was associated with lower FPG, 1-h PG, 2-h PG and HbA1c, with the strongest association observed for 1-h PG (β per 1-SD increase -1.189 mmol/L; p < 0.001). During follow-up, 136 participants progressed to diabetes and 61 reverted to normoglycemia. Each 1-SD increase in ISSI-2 was associated with lower progression risk (OR 0.505, 95% CI: 0.382-0.668) and higher likelihood of reversion (OR 1.447, 95% CI: 1.106-1.893), whereas HOMA-IR showed less consistent associations. Compared with the Low IR + higher ISSI-2 group, the dual-defect group (higher HOMA-IR and lower ISSI-2) had higher progression risk (OR 2.764, 95% CI: 1.459-5.237).
conclusionsISSI-2 was associated with baseline glycaemic profiles and bidirectional 2-year transitions in Chinese adults with prediabetes. OGTT-derived β-cell function assessment may complement conventional glycaemic classification for short-term risk stratification, pending validation in independent cohorts.
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