Heart failure-induced reprogramming of salt-evoked neurovascular coupling in the rat hypothalamus.

Ranjan K Roy, Elba Campos Lira, Manuel Bita Ongolo, Jessica A Filosa, Javier E Stern

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Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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5 · Who and what money

Authors and funding

5 authors.

Ranjan K RoyNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-6234-8043

Elba Campos LiraNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0001-9476-5287

Manuel Bita OngoloNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0005-9245-2112

Jessica A FilosaDepartment of Physiology, Augusta University, Augusta, Georgia, USA.

Javier E SternNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.

Funding

Inverse neurovascular coupling in the hypothalamus and its role in positive feedback regulation of Vasopressin neurons in health and diseaseR01HL162575 · NHLBI · GEORGIA STATE UNIVERSITY · PI FILOSA, JESSICA A, STERN, JAVIER E · 2022 to 2025

$2.7M

American Heart Association 916907NHLBI NIH HHS R01 HL162575NHLBI NIH HHS R01HL162575

6 · The paper itself

Abstract

Neurovascular coupling (NVC) is essential for matching cerebral blood flow to neuronal activity. While NVC has been extensively studied in the cerebral cortex, far less is known about its regulation in deep brain regions such as the hypothalamus, particularly under pathological conditions. Heart failure (HF) is associated with impaired cortical NVC and cognitive dysfunction, but its impact on hypothalamic NVC remains unclear. Here, we investigated salt-evoked NVC in the hypothalamic supraoptic nucleus (SON) of rats with HF. In vivo two-photon imaging combined with real-time tissue oxygen measurements was used to assess parenchymal arteriole diameter and local

Indexed as

Heart FailureHypothalamusNeurovascular CouplingSupraoptic NucleusAnimalsArginine VasopressinCerebrovascular CirculationMaleRatsRats, Sprague-DawleyVasodilationVasopressinsArginine VasopressinVasopressinsadenosincardiovascularheart failuremicrogliasaltvascularvasopressin

Identifiers

PMID42733142

DOI10.1113/JP290864

PMCPMC13577701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.