Evidence map›Paper›PMID 42733093›Full record

Observational studyNature medicine2026

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC.

Arsela Prelaj, Vanja Miskovic, Matteo Sacco, Alberto Ferrarin, Cristina Maria Licciardello, Leonardo Provenzano, Margherita Favali, Ludovica Lerma, Aleksandra Zec, Andrea Spagnoletti and 68 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

78 authors.

Arsela Prelaj *Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. arsela.prelaj@istitutotumori.mi.it.ORCID http://orcid.org/0000-0002-3863-088X
Vanja Miskovic *Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0000-0003-1475-0243
Matteo SaccoDepartment of Medicine, Section of Hematology Oncology, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA.
Alberto FerrarinMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0009-0004-8915-5750
Cristina Maria LicciardelloMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0009-0008-1650-5309
Leonardo ProvenzanoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Margherita FavaliMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Ludovica LermaMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0009-0005-1622-5348
Aleksandra ZecMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Andrea SpagnolettiMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Monica GanzinelliMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Daniele LorenziniDepartment of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Beshoy GuirgesMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0009-0005-5544-3591
Luca InvernizziMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Cecilia SilvestriMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Laura MazzeoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0000-0001-9226-8861
Marco Meazza PrinaMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Giulia CorraoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0000-0002-5757-6073
Margherita RuggirelloMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Andra Diana DumitrascuMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Rosa Maria Di MauroMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Dario MonzaniApplied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS, Milan, Italy.
Gabriella PravettoniApplied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS, Milan, Italy.
Michele ZanittiDepartment of Electronic Systems, Aalborg University, Copenhagen, Denmark.
Davide MacocchiML cube, Milan, Italy.
Moreno Bruno MarinoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Chiara CavalliMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Rebecca RomanòMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Claudia GianiMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Samuel G ArmatoDepartment of Radiology, The University of Chicago, Chicago, IL, USA.
Alessandra EspositoDepartment of Medicine, Section of Hematology Oncology, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-0664-3122
Christine M BestvinaDepartment of Medicine, Section of Hematology Oncology, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7189-1590
Maria SpectorShaare Zedek Medical Center, Jerusalem, Israel.
Bogot R NaamaShaare Zedek Medical Center, Jerusalem, Israel.
Reham BasheerShaare Zedek Medical Center, Jerusalem, Israel.
Adi Lahiani HafzadiShaare Zedek Medical Center, Jerusalem, Israel.
Laila RoismanShaare Zedek Medical Center, Jerusalem, Israel.ORCID http://orcid.org/0000-0001-8455-9327
Iris WatermannLungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.ORCID http://orcid.org/0000-0002-7528-4998
Marlen SzewczykLungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.
Till OlchersLungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.
Heinz RichterLungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.
Constantin Blanke-RoeserLungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.
Costanza SiniscalchiDepartment of Medicine, Section of Hematology Oncology, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0003-4481-0929
Anna Di LelloDepartment of Medicine, Section of Hematology Oncology, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0000-3235-5787
Teresa ArangoaDepartment of Medical Oncology, Hospital Universitario de La Princesa, Madrid, Spain.
Valentina BartolomeoDepartment of Oncology and Hemato-oncology, University of Milan, Milan, Italy.ORCID http://orcid.org/0009-0007-1493-7282
Nikolaos Spathas4th Oncology Department & Comprehensive Clinical Trials Center, Metropolitan Hospital, Athens, Greece.
Evangelos Sarris4th Oncology Department & Comprehensive Clinical Trials Center, Metropolitan Hospital, Athens, Greece.
Elena FountzilasDepartment of Medical Oncology, St. Luke's Clinic, Thessaloniki, Greece.
Aina Arbusà RocaThoracic Tumors Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7053-7386
Rocio Caro-ConsuegraThoracic Tumors Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID http://orcid.org/0009-0003-8562-6132
Patricia IranzoThoracic Tumors Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9335-2472
Melissa Fernández-PintoMedica Scientia Innovation Research (MEDSIR), Barcelona, Spain.
Jose Rodríguez-MoratóMedica Scientia Innovation Research (MEDSIR), Barcelona, Spain.ORCID http://orcid.org/0000-0002-8133-9983
Luca AgnelliDepartment of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0000-0003-0582-6170
Mario OcchipintiMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Marta BrambillaMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Teresa BeninatoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID http://orcid.org/0000-0003-0388-6655
Claudia ProtoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Sokol KostaDepartment of Electronic Systems, Aalborg University, Copenhagen, Denmark.
Michele Pio Di PalmaMethodology for Clinical Research Laboratory, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Eliana RulliMethodology for Clinical Research Laboratory, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Stefan SteurerInstitute for Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ronald SimonInstitute for Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-0158-4258
Michael WillisThe Swedish Institute for Health Economics, Lund, Sweden.
Giancarlo PruneriDepartment of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Filippo De BraudDepartment of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Marcello RestelliDepartment of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy.
Enriqueta FelipThoracic Tumors Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Nir PeledShaare Zedek Medical Center, Jerusalem, Israel.
Alexander T PearsonDepartment of Medicine, Section of Hematology Oncology, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA.
Helena Linardou4th Oncology Department & Comprehensive Clinical Trials Center, Metropolitan Hospital, Athens, Greece.ORCID http://orcid.org/0000-0002-2906-6607
Martin ReckLungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.
Giuseppe Lo RussoMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Francesco TrovòDepartment of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy.ORCID http://orcid.org/0000-0001-5796-7667
Alessandra Laura Giulia PedrocchiDepartment of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy.ORCID http://orcid.org/0000-0001-9957-2786
Marina Chiara GarassinoDepartment of Medicine, Section of Hematology Oncology, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA.
I3LUNG Consortium

Funding

European Commission (EC) 101057695
6 · The paper itself

Abstract

Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I

Indexed as

Artificial IntelligenceCarcinoma, Non-Small-Cell LungDecision Support Systems, ClinicalLung NeoplasmsAgedB7-H1 AntigenDeep LearningFemaleHumansImmunotherapyMachine LearningMaleMiddle AgedTomography, X-Ray ComputedB7-H1 Antigen

Identifiers

PMID42733093
PMCPMC13577906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.