Evidence map›Paper›PMID 42733006›Full record

ArticleNature communications2026

TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation.

Yu-Yu Chen, Dong-Ting Ke, Yen-Chun Lee, Hong-Ru Chen, Hsiang-Ying Lin, Chun-Hsin Yeh, Yu-Ching Ko, Meng-Han Tu, Chien-Hung Yu, Zhenyi Hu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu-Yu Chen *Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0009-0006-6242-9947
Dong-Ting Ke *Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yen-Chun Lee *Department of Chemistry, College of Science, National Cheng Kung University, Tainan, Taiwan.
Hong-Ru Chen *Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-9016-2190
Hsiang-Ying LinDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chun-Hsin YehDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0009-0006-4622-3674
Yu-Ching KoDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Meng-Han TuDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chien-Hung YuDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Zhenyi HuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Po-Han ChenDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. pohanchenbmb@gs.ncku.edu.tw.ORCID http://orcid.org/0000-0002-9471-4471

Funding

Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 113-2628-B-006-004Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 114-2320-B-006-027-MY3Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 114-2628-B-006-014National Health Research Institutes (NHRI) EX113-11308BCNational Health Research Institutes (NHRI) EX114-11308BCNational Health Research Institutes (NHRI) EX115-11308BC
6 · The paper itself

Abstract

Phosphorylation-targeting chimeras (PhosTACs) enable targeted protein dephosphorylation by recruiting phosphatases through induced proximity. However, the direct recruitment of phosphatase subunits or holoenzymes with small molecules remains challenging, as suitable ligands are scarce and often compromise enzymatic activity or cellular function. Here, we present togoPhosTAC, a hybrid modality that integrates a small-molecule PhosTAC, an engineered FKBP12

Indexed as

Phosphoric Monoester HydrolasesPhosphorylationalpha-SynucleinAlzheimer DiseaseAnimalsErbB ReceptorsHumansMaleMiceMice, TransgenicNanoparticlesTacrolimus Binding Protein 1Atau Proteinsalpha-SynucleinErbB ReceptorsPhosphoric Monoester HydrolasesTacrolimus Binding Protein 1Atau Proteins

Identifiers

PMID42733006
PMCPMC13572435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.