Evidence map›Paper›PMID 42732975›Full record

ArticleBritish journal of haematology2026

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity.

Matthias Bleeke, Arne Simon, Beate Winkler, Sabine Heine, Anna Eichinger, Ulrich von Both, Meinolf Siepermann, Sonya El Amouri, Arndt Borkhardt, Yvonne Pritschow and 33 more

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Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Matthias BleekeDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0003-0455-8338
Arne SimonPediatric Hematology and Oncology, Saarland University Hospital and Saarland University Faculty of Medicine, Homburg, Germany.ORCID https://orcid.org/0000-0001-9558-3330
Beate WinklerDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-4050-9819
Sabine HeinePediatric Hematology and Oncology, Saarland University Hospital and Saarland University Faculty of Medicine, Homburg, Germany.ORCID https://orcid.org/0009-0006-4856-7016
Anna EichingerDepartment of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital LMU, Munich, Germany.ORCID https://orcid.org/0000-0002-2256-6633
Ulrich von BothDepartment of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital LMU, Munich, Germany.
Meinolf SiepermannDepartment of Pediatric Hematology and Oncology, Children's Hospital Amsterdamer Straße, Cologne, Germany.ORCID https://orcid.org/0009-0006-3082-0132
Sonya El AmouriDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID https://orcid.org/0009-0004-5820-7298
Arndt BorkhardtDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID https://orcid.org/0000-0002-6121-4737
Yvonne PritschowDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Wolfgang NovakDepartment of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0009-0007-9014-5658
Michael DworzakDepartment of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-8175-1097
Sarah GoretzkiDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0001-5218-070X
Clara HeldDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University of Duisburg-Essen, Essen, Germany.
Karin BeutelDepartment of Pediatrics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Franziska GamsDepartment of Pediatrics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Henriette RudolphDepartment of Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-3809-4861
Leila KoscherDepartment of Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany.
Piet E BeuskerDepartment of Pediatrics, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University, Bielefeld, Germany.ORCID https://orcid.org/0009-0008-2656-6762
Eckard HamelmannDepartment of Pediatrics, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University, Bielefeld, Germany.ORCID https://orcid.org/0000-0002-2996-8248
Stefan WeichertDepartment of Pediatric Oncology, University of Mannheim, Mannheim, Germany.
Svenja HäuserDepartment of Pediatric Oncology, University of Mannheim, Mannheim, Germany.
Maximilian MauritzDepartment of Pediatrics, Children's and Adolescent's Hospital Datteln, Witten/Herdecke University, Datteln, Germany.ORCID https://orcid.org/0000-0002-9618-5307
Malik AydinDepartment of Pediatrics, Children's and Adolescent's Hospital Datteln, Witten/Herdecke University, Datteln, Germany.
Verena WiegeringDepartment of Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany.
Regine GrosseDepartment of Pediatric Hematology and Oncology, Gemeinschaftsklinikum Mittelrhein, Koblenz, Germany.
Rainer MisgeldDepartment of Pediatric Hematology and Oncology, Gemeinschaftsklinikum Mittelrhein, Koblenz, Germany.ORCID https://orcid.org/0009-0007-0081-4070
Martina StiefelUniversity Hospital Halle (Saale), Department of Pediatrics I, Martin Luther University Halle-Wittenberg, Halle, Germany.ORCID https://orcid.org/0009-0002-3277-7212
Nicole TöpfnerDepartment of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Uta FalkeDepartment of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Lara ImhofDepartment of Pediatrics, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Laura TagliaferriDepartment of Pediatric Oncology, Haematology and Immunology, Hopp-Children's Cancer Center (KiTZ) Heidelberg, University of Heidelberg, Heidelberg, Germany.
Daniel Ebrahimi-FakhariPediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.ORCID https://orcid.org/0000-0002-3097-141X
Andreas GrollPediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.ORCID https://orcid.org/0000-0003-1188-393X
Marion AppelDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.
Nora Naumann-BartschDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.ORCID https://orcid.org/0000-0001-5606-9822
Michaela NathrathDepartment of Pediatric Hemato-Oncology, Psychosomatics and Systemic Diseases, Klinikum Kassel, Kassel, Germany.
Olaf BeckDepartment of Pediatric Hematology/Oncology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID https://orcid.org/0000-0002-7448-6029
Solvej HeidtmannDepartment of Pediatrics, Ruhr University Bochum, Johannes-Wesling-Klinikum Minden, Minden, Germany.ORCID https://orcid.org/0009-0002-5859-5986
Philipp TischerDepartment of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ulf Schulze-SturmDepartment of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0001-9539-5356
Urs MückeDepartment of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-0240-248X
Holger CarioDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.ORCID https://orcid.org/0000-0002-6923-488X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections between 2023 and 2025, including symptoms, laboratory parameters, diagnostic procedures and treatment details to detect differences between SCD genotypes (HbSS and HbS/β

Indexed as

Anemia, Sickle CellHydroxyureaParvoviridae InfectionsParvovirus B19, HumanAdolescentAntisickling AgentsChildChild, PreschoolFemaleGenotypeHumansMaleRetrospective StudiesSeverity of Illness IndexAntisickling AgentsHydroxyureaparvovirus B19sickle cell disease

Identifiers

PMID42732975
PMCPMC13674147

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.