Evidence map›Paper›PMID 42732909›Full record

ArticleChemMedChem2026

Schiff Base Derivatives of Benzothiazole and Benzamide as Promising Antimicrobial Agents: Integrated In Silico and In Vitro Evaluation.

Temitope A Ogunnupebi, Gbolahan O Oduselu, Oluwadunni F Elebiju, Oluwabukayo T Opebiyi, Natasha October, Olayinka O Ajani, Ezekiel Adebiyi

Abstract read
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Temitope A OgunnupebiCovenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.ORCID https://orcid.org/0000-0002-0744-7812
Gbolahan O OduseluCovenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.ORCID https://orcid.org/0000-0003-0136-1732
Oluwadunni F ElebijuCovenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.ORCID https://orcid.org/0000-0002-3005-7003
Oluwabukayo T OpebiyiDepartment of Chemistry, Covenant University, Ota, Ogun State, Nigeria.ORCID https://orcid.org/0009-0003-6066-5952
Natasha OctoberDepartment of Chemistry, University of Pretoria, Hatfield, South Africa.ORCID https://orcid.org/0000-0001-5163-9267
Olayinka O AjaniCovenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.ORCID https://orcid.org/0000-0002-3422-3478
Ezekiel AdebiyiAfrican Center of Excellence in Bioinformatics and Data Intensive Science, Makerere University, Kampala, Uganda.

Funding

WEST AFRICAN SUSTAINABLE LEADERSHIP AND INNOVATION TRAINING IN BIOINFORMATICS RESEARCH (WASLITBRe)U2RTW010679 · FIC · COVENANT UNIVERSITY · PI ADEBIYI, EZEKIEL FEMI, AMOAKO-YIRENKYI, PETER · 2017 to 2021
$1.4M
FIC NIH HHS U2R TW010679FIC NIH HHS U2RTW010679Royal Society of Chemistry R21-245685027
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) remains a critical global health challenge, demanding new scaffolds with potent and broad-spectrum activity. In this work, a library of Schiff-base derivatives of benzothiazoles (2a-2f) and benzamides (5a-5i) was designed, synthesised via a microwave-assisted approach, and comprehensively characterised by

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBenzamidesBenzothiazolesCandida albicansEscherichia coliGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)Gram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureSchiff BasesSterol 14-DemethylaseStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsBenzamidesbenzothiazoleBenzothiazolesGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)Schiff BasesSterol 14-Demethylaseantimicrobial activitybenzamide derivativesbenzothiazole derivativesin silico ADMETmolecular docking

Identifiers

PMID42732909
PMCPMC13572031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.