Evidence map›Paper›PMID 42732880›Full record

ArticlePsyCh journal2026

Elevated Plasma DISC1 Levels Are Associated With Motivational Deficits in Medication-Free Patients With Major Depressive Disorder: An Exploratory Study.

Zhenhua Zhu, Xuyuan Yin, Jia Huang, Yi Wang, Qi Qi, Peijie Wang, Simon S Y Lui, Li Hui, Raymond C K Chan

Abstract read
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In one paragraph

Article in PsyCh journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhenhua ZhuNeuropsychology and Applied Cognitive Neuroscience Laboratory, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Xuyuan YinResearch Center of Biological Psychiatry, Suzhou Guangji Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Jia HuangNeuropsychology and Applied Cognitive Neuroscience Laboratory, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-7269-6797
Yi WangNeuropsychology and Applied Cognitive Neuroscience Laboratory, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-6880-5831
Qi QiResearch Center of Biological Psychiatry, Suzhou Guangji Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Peijie WangResearch Center of Biological Psychiatry, Suzhou Guangji Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Simon S Y LuiDepartment of Psychiatry, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0001-9360-6244
Li HuiResearch Center of Biological Psychiatry, Suzhou Guangji Hospital, Suzhou Medical College of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0001-6162-1335
Raymond C K ChanNeuropsychology and Applied Cognitive Neuroscience Laboratory, State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-3414-450X

Funding

Jiangsu Provincial Administration of Traditional Chinese Medicine MS2022083Jiangsu Provincial Key Research and Development Program BE2020661National Natural Science Foundation of China 81771439National Natural Science Foundation of China 82371508Natural Science Foundation of Jiangsu Province BK20200210Sample Bank of Suzhou Municipal Psychiatric DisordersSuzhou Municipal Finance BureauSuzhou Municipal Health Commission Science Research Program ZDXM2025019Suzhou Municipal Sci-Tech Bureau Program SKY2022065
6 · The paper itself

Abstract

Disrupted-in-Schizophrenia 1 (DISC1) has been implicated in major psychiatric disorders, but the relationship between circulating DISC1 protein and dimensional motivation and pleasure-related features in major depressive disorder (MDD) is unknown. This exploratory cross-sectional study compared plasma DISC1 levels between 55 medication-free patients with MDD and 55 healthy controls (HCs) and examined associations with Clinical Assessment Interview for Negative Symptoms (CAINS) scores. Plasma DISC1 was measured by enzyme-linked immunosorbent assay, and the CAINS Motivation and Pleasure (MAP) and Expression (EXP) domains were assessed. Patients with MDD had higher CAINS-MAP, CAINS-EXP, and total scores; plasma DISC1 levels were nominally higher after covariate adjustment. In MDD, log

Indexed as

Major Depressive DisorderMotivationNerve Tissue ProteinsAdultBiomarkersCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedBiomarkersDISC1 protein, humanNerve Tissue ProteinsCAINSDISC1major depressive disordermotivation and pleasureplasma biomarker

Identifiers

PMID42732880
PMCPMC13571855

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.