Microfluidic Platforms for Cryopreservation.

Gang Zhao

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Gang ZhaoLaboratory for Cryo-Biomedical Engineering, Department of Electronic Engineering and Information Science, School of Information Science and Technology, University of Science and Technology of China, Hefei, China. zhaog@ustc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This chapter examines the application of microfluidics in cryopreservation, addressing the limitations of conventional techniques and highlighting how microfluidic approaches overcome these challenges. It delves into the fundamental principles of microfluidic cryopreservation, including microscale heat and mass transfer dynamics, precise control of cryoprotective agents (CPAs), and ultra-rapid cooling/warming. The chapter also showcases key applications, including on-chip cell membrane permeability measurement, dynamic CPA addition/removal, and integrated cryopreservation workflows on microfluidic platforms. Finally, it explores the transformative potential of microfluidics in enabling more precise, controllable, and efficient cryopreservation methods, while outlining future research directions and potential technological synergies.

Indexed as

CryopreservationMicrofluidic Analytical TechniquesMicrofluidicsAnimalsCell Membrane PermeabilityCryoprotective AgentsHumansLab-On-A-Chip DevicesVitrificationCryoprotective AgentsCell membrane permeabilityCryopreservationCryoprotective agents (CPAs)Heat and mass transferMicrochannelMicrofluidicsOsmotic stressUltra-rapid cooling/warmingVitrification

Identifiers

PMID42732497

DOI10.1021/acsmacrolett.5c00129

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.