ArticleJournal of research in pharmacy practice2026
Magnesium Sulfate as an Analgesic and Sedative-sparing Agent in Patients under Mechanical Ventilation: A Randomized, Double Blind Clinical Trial.
Article in Journal of research in pharmacy practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Objectives: The efficacy of intravenous magnesium sulfate in reducing sedative and analgesic requirements was examined in patients under mechanical ventilation. Methods: In this randomized clinical trial, patients requiring mechanical ventilation received either magnesium sulfate (serum magnesium target level: near 3 mg/dL) or placebo concurrently with the hospital analgosedation protocol. The calculated dose of magnesium in the intervention group was infused over 24 h. The primary outcome of the study was the cumulative opioid requirement at 24 and 48 h after intubation. Findings: A total of 110 patients were randomly assigned to either the placebo ( Conclusion: Administration of magnesium sulfate targeting a serum magnesium level near 3 mg/dL in patients under mechanical ventilation reduced opioid requirements and may be considered as an analgesic and sedative-sparing agent.
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