Evidence map›Paper›PMID 42732187›Full record

ArticleMedComm2026

SKP2 Regulates Pulmonary Inflammatory Injury Triggered by Bacterial Infection Through p27-Mediated Degradation of FOXN3.

Jinjin Yu, Xinghong Hu, Huanhuan Wang, Jingyu Yu, Lele Jin, Yingke Li, Jihong Zhou, Xinxing Zhu, Emmanuel Jairaj Moses, Chunfu Zheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinjin YuAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.
Xinghong HuAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.
Huanhuan WangAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.
Jingyu YuAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.
Lele JinAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.
Yingke LiHenan Joint International Research Laboratory of Stem Cell Medicine, School of Medical Engineering Xinxiang Medical University Xinxiang China.
Jihong ZhouResearch Center of Clinical Laboratory Science, School of Laboratory Medicine Bengbu Medical University Bengbu China.
Xinxing ZhuAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.
Emmanuel Jairaj MosesRegenerative Medicine Sciences Cluster, Advanced Medical and Dental Institute Universiti Sains Malaysia Kepala Batas Malaysia.
Chunfu ZhengDepartment of Microbiology, Immunology & Infection Diseases University of Calgary Calgary Alberta Canada.
Yong ZhangAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.
Wei LiAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University Bengbu China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive inflammatory responses are a primary driver of acute lung injury, yet the underlying molecular mechanisms remain incompletely understood. In this study, we identify SKP2, an E3 ubiquitin ligase, as a critical negative regulator of pulmonary inflammation during methicillin-resistant

Indexed as

noncanonical NF‐κB signalingp27kip1phosphorylationpulmonary inflammatory injurySKP2

Identifiers

PMID42732187
PMCPMC13570262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.