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ReviewF1000Research2025

Case Report: Giant Malignant Phyllodes Tumor of the Breast: Immediate Reconstruction with a Pedicled Latissimus Dorsi Myocutaneous Flap Following Total Mastectomy-A Case Report and Review of Reconstructive Considerations.

Dhekra Toumi, Chayma Cheikh Mohamed, Ahmed Hajji, Imen Ghaddab, Malak Medemagh, Hanane Lazreg, Yasmine Ben Ali, Sana Alouani, Jawaher Hammedi, Selma Souilah and 7 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Dhekra ToumiObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Chayma Cheikh MohamedObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.ORCID https://orcid.org/0009-0004-8360-4543
Ahmed HajjiObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Imen GhaddabObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.ORCID https://orcid.org/0000-0002-7341-199X
Malak MedemaghObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.ORCID https://orcid.org/0009-0009-1278-5777
Hanane LazregObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Yasmine Ben AliObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Sana AlouaniObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Jawaher HammediObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Selma SouilahObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Rihab BarouniObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Hiba Ben AbdelhafidhObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.ORCID https://orcid.org/0009-0006-0134-611X
Sana BouakezObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Thana MahfoudhiObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Olfa ZoukarObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.ORCID https://orcid.org/0000-0001-9746-3359
Haifa BergaouiObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.
Raja FalehObstetrics and Gynecology Department, Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of Monastir, Monastir, Monastir, 5030, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phyllodes tumor of the breast is a rare fibroepithelial tumor, constituting less than 1% of all breast neoplasms. These tumors are characterized by rapid stromal growth and can reach significant sizes, particularly in malignant cases, necessitating aggressive surgical management due to their high recurrence risk. In this case report, we present a 40-year-old Tunisian woman diagnosed with a giant phyllodes sarcoma. The patient experienced considerable physical and psychological impacts, including impaired mobility, body image disruption, and professional limitations. Clinical examination and imaging confirmed the presence of a large lobulated mass in the left breast, with no signs of distant metastasis. A multidisciplinary team recommended a total mastectomy with immediate reconstruction using a latissimus dorsi myocutaneous flap. This approach aimed to restore breast contour while addressing both oncologic and aesthetic needs. The procedure was successful, with the excised tumor weighing 7 kg. Postoperatively, the patient received close monitoring and psychological support, emphasizing the importance of a holistic approach to recovery. This case underscores the complexities of managing giant phyllodes sarcoma, highlighting the value of a timely surgical intervention combined with effective reconstructive techniques. It also emphasizes the need for individualized treatment plans that consider both functional and aesthetic outcomes to optimize patient recovery and quality of life.

Indexed as

Breast NeoplasmsMammaplastyMastectomyMyocutaneous FlapPhyllodes TumorPlastic Surgery ProceduresSuperficial Back MusclesAdultFemaleHumansbody imageBreast oncologyGiant breast tumorLatissimus dorsi flap reconstructionmastectomyPhyllodes sarcomaquality of lifeReconstructive surgery

Identifiers

PMID42732157
PMCPMC13563010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.