ArticleNPJ systems biology and applications2026
Bacterial and fungal communities and network dynamics in Otitis media patients upon 1,8-Cineol treatment.
Article in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the bacterial and fungal communities and cross-domain network interactions in patients with chronic Otitis media in response to the natural monoterpene medicinal 1,8-Cineol as a promising treatment option. While the bacterial community showed modest changes with preserved core genera, the fungal community underwent dramatic diversification and network expansion. This suggests that treatment may have disrupted competitive exclusion mechanisms in the latter, allowing for increased diversity and interactions, despite no significant changes in traditional diversity metrics. Investigations on the microbial community compositions in Otitis media patients upon 1,8-Cineol treatment revealed significantly different initial microbial signatures in responders and non-responders. Notably, therapy-responding COM patients demonstrated a baseline situation with significantly higher abundances of different gram-negative Pseudomonas species. In contrast, significantly elevated levels of various gram-positive Corynebacterium species were observed in the non-responder group compared to the 1,8-Cineol responding patients. These keystone taxa may represent new targets for therapeutic intervention or biomarkers for treatment response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.