ReviewArchives of toxicology2026
In vitro approaches for modelling gut-liver crosstalk in drug-induced liver injury.
Review in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Drug-induced liver injury (DILI) remains a major challenge in drug development and clinical practice due to its limited predictability in current preclinical models. Increasing evidence indicates that the gut-liver axis, through bidirectional interactions between the gut and the liver, plays an important role in modulating drug metabolism and hepatotoxicity. Nevertheless, the exact role of our gut, its microbiota and microbiota-derived metabolites in the manifestation of DILI remains poorly understood, highlighting the need for more human-relevant in vitro models taking along gut-liver interactions. To address this need, this review paper aimed to map the current landscape of in vitro gut-liver models and evaluate their potential applicability for future DILI research. A literature screening using the PubMed database identified 95 articles published on this subject between 2000 and 2026. The in vitro models were categorized into 5 groups, including monocultures, Transwell
Indexed as
Identifiers
42731995What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.