Evidence map›Paper›PMID 42731862›Full record

Observational studyOpen heart2026

P2Y

Kerrick Hesse, Jessica Stephens, Jonathan A Batty, Christopher David Bayliss, Saif Memon, Shu Xian Loh, Pyotr Telyuk, Neil Swanson, Douglas Muir, Matthew Jackson and 7 more

Abstract readObservational Study
In one paragraph

Observational study in Open heart, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kerrick HesseAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK kerrick.hesse@nhs.net.ORCID http://orcid.org/0000-0002-1155-0409
Jessica StephensYork Hospitals NHS Foundation Trust, York, UK.
Jonathan A BattyAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Christopher David BaylissAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Saif MemonAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Shu Xian LohAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Pyotr TelyukAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Neil SwansonAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Douglas MuirAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Matthew JacksonAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Justin CarterAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Andrew SuttonAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Sethumadhavan VijayanAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Paul D WilliamsAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Enoch AkowuahAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.ORCID http://orcid.org/0000-0002-2429-3579
Chris WilkinsonAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
David AustinAcademic Cardiovascular Unit, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDual antiplatelet therapy is indicated in the management of non-ST-elevation acute coronary syndrome (NSTE-ACS) and can be administered before coronary angiography (pre-treatment) or after coronary anatomy is known. Based on clinical trials with rapid access to inpatient coronary angiography, clinical guidelines recommend invasive assessment prior to commencing a second antiplatelet. We aimed to evaluate the impact of a change in clinical policy from routine P2Y

methodsA retrospective observational study of hospitalised NSTE-ACS patients with a planned invasive strategy at a tertiary cardiac centre in Northeast England was conducted. Two cohorts were identified:

resultsOf 2506 NSTE-ACS cases, 1219 presented before and 1287 after the policy change, which was adhered to in most cases (84.2%). Median time from admission to angiography was 3.6 days (IQR 1.9, 5.8). In comparison to a

conclusionWe observed a greater risk of in-hospital STEMI but lower rates of bleeding following the change from a

Indexed as

Acute Coronary SyndromeNon-ST Elevated Myocardial InfarctionPurinergic P2Y Receptor AntagonistsAgedCoronary AngiographyEnglandFemaleHemorrhageHumansMaleMiddle AgedPlatelet Aggregation InhibitorsRetrospective StudiesRisk FactorsST Elevation Myocardial InfarctionTime FactorsPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsAcute Coronary SyndromeCoronary AngiographyHealth Services

Identifiers

PMID42731862
PMCPMC13583690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.