Ultrasound-assisted extraction of flavonoids from Blumea balsamifera using deep eutectic solvents: optimization, characterization, and antioxidant evaluation.

Wei Dai, Liping Dai, Lei Jin, Rui Pang, Sina Wang, Hongfeng Chen, Xilong Zheng

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Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Wei DaiTeaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou 510006, China; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Yunfu Campus, Guangdong Pharmaceutical University, Yunfu 527500, China. Electronic address: dai_gdpu_2018@gdpu.edu.cn.

Liping DaiCollege of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu 527325, China; Fogang County Maternal and Child Health Hospital, Fogang 511600, China; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. Electronic address: 16680128026@163.com.

Lei JinTeaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou 510006, China; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Yunfu Campus, Guangdong Pharmaceutical University, Yunfu 527500, China. Electronic address: jinlei@gdpu.edu.cn.

Rui PangTeaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou 510006, China; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Yunfu Campus, Guangdong Pharmaceutical University, Yunfu 527500, China. Electronic address: pangrui@gdpu.edu.cn.

Sina WangTeaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou 510006, China; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Yunfu Campus, Guangdong Pharmaceutical University, Yunfu 527500, China. Electronic address: wangsn@gdpu.edu.cn.

Hongfeng ChenKey Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. Electronic address: h.f.chen@scbg.ac.cn.

Xilong ZhengCollege of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu 527325, China. Electronic address: zhengxl2020@gdpu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blumea balsamifera, a traditional medicinal herb rich in flavonoids, is recognized for its strong antioxidant potential. In this study, a sustainable extraction strategy combining deep eutectic solvents (DES) and ultrasound-assisted extraction (UAE) was developed to enhance flavonoid recovery. Extraction parameters were optimized using response surface methodology (RSM) for DES screening, and further refined by an artificial neural network-genetic algorithm model (ANN-GA). Choline chloride-glycerol (ChCl-Gly, 1:2, 40% water) was selected as the optimal solvent. Under the ANN-GA conditions of 40:1 mL/g, 77 °C, 45 min, and 300 W, the total flavonoid yield reached 3.52 ± 0.01%, which was 73.40% higher than that obtained by 50% ethanol heat-assisted extraction. Factorial, kinetic, rated-power-based operational, and SEM analyses were consistent with ultrasound-associated matrix disruption and mass-transfer intensification, while FTIR and

Indexed as

AntioxidantsAsteraceaeChemical FractionationDeep Eutectic SolventsFlavonoidsUltrasonic WavesSolventsAntioxidantsDeep Eutectic SolventsFlavonoidsSolventsAntioxidant activityBlumea balsamiferaDeep eutectic solventsFlavonoidsGreen chemistryUltrasound-assisted extraction

Identifiers

PMID42731575

DOI10.1016/j.ultsonch.2026.108053

PMCPMC13587741

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