Evidence map›Paper›PMID 42731173›Full record

ArticleThe journal of prevention of Alzheimer's disease2026

Characterization of a metabolomics signature of the brain-health-promoting MIND diet in older persons.

Jeanne Neuffer, Raúl González-Domínguez, Sophie Lefèvre-Arbogast, Dorrain Y Low, Alba Tor-Roca, Catherine Helmer, Andrea Du Preez, Chiara de Lucia, Silvie R Ruigrok, Barbara Altendorfer and 10 more

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Article in The journal of prevention of Alzheimer's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Jeanne NeufferUniversity of Bordeaux, Inserm Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France; University Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, F-91120, Palaiseau, France. Electronic address: jeanne.neuffer@agroparistech.fr.
Raúl González-DomínguezNutrition, Food Science and Gastronomy Department, Institute of Nutrition and Food Safety (INSA-UB), Faculty of Pharmacy and Food Science, University of Barcelona, 08028, Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Sophie Lefèvre-ArbogastUniversity of Bordeaux, Inserm Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France.
Dorrain Y LowUniversity Clermont Auvergne, INRAE, UMR1019, Human Nutrition Unit, F-63000, Clermont Ferrand, France; Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore.
Alba Tor-RocaNutrition, Food Science and Gastronomy Department, Institute of Nutrition and Food Safety (INSA-UB), Faculty of Pharmacy and Food Science, University of Barcelona, 08028, Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Catherine HelmerUniversity of Bordeaux, Inserm Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France.
Andrea Du PreezDepartment of Nutritional Sciences, School of Life Course & Population Sciences, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
Chiara de LuciaDepartment of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
Silvie R RuigrokBrain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.
Barbara AltendorferInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, 5020, Austria.
Ludwig AignerInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, 5020, Austria.
Paul J LucassenBrain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands; The Center for Urban Mental Health, University of Amsterdam, the Netherlands.
Aniko KorosiBrain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.
Sandrine ThuretDepartment of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
Claudine ManachUniversity Clermont Auvergne, INRAE, UMR1019, Human Nutrition Unit, F-63000, Clermont Ferrand, France.
Mercè PallàsPharmacology Section, Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Neurociencies, University of Barcelona, E-08028, Barcelona, Spain.
Alex Sánchez-PlaNutrition, Food Science and Gastronomy Department, Institute of Nutrition and Food Safety (INSA-UB), Faculty of Pharmacy and Food Science, University of Barcelona, 08028, Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Cristina Andres-LacuevaNutrition, Food Science and Gastronomy Department, Institute of Nutrition and Food Safety (INSA-UB), Faculty of Pharmacy and Food Science, University of Barcelona, 08028, Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Mireia Urpi-SardaNutrition, Food Science and Gastronomy Department, Institute of Nutrition and Food Safety (INSA-UB), Faculty of Pharmacy and Food Science, University of Barcelona, 08028, Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Cécilia SamieriUniversity of Bordeaux, Inserm Bordeaux Population Health Research Center, UMR 1219, F-33000, Bordeaux, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe MIND diet supports healthy cognitive aging. Yet, a challenge remains to identify individuals who do not adhere to the MIND and could be at risk for accelerated cognitive decline. A multi-metabolite biomarker panel could facilitate population screening.

objectivesTo determine and validate a blood metabolomics signature of MIND adherence in a large cohort of older adults, and to estimate its association with subsequent cognitive decline. DESIGN, SETTING AND

participantsParticipants were older adults (≥65 years) from the population-based three-City (3C) cohort, free of dementia at study baseline and followed for up to 12 years for cognition, who were included in two case-control samples on cognitive decline nested within two centers (Bordeaux and Dijon cities, n = 838). EXPOSURES: 155 diet-related serum metabolites measured with a multianalyte metabolomics platform. MAIN OUTCOMES AND MEASUREMENTS: The primary outcome was adherence to the MIND diet, assessed in a subsample of 344 participants from Bordeaux center (which underwent the dietary surveys, 24 h recall and food-frequency questionnaire). A metabolomics signature of MIND diet adherence was characterized with penalized regression and a metabolomics score ("metaboscore") reflecting the overall MIND biological fingerprint was calculated. The secondary outcome was cognitive decline status (coded as binary: accelerated, vs. null or minimal decline) over follow-up, assessed using repeated cognitive measures in the two case-control samples. The metaboscore was reconstructed and linked to the odds of cognitive decline.

resultsEight metabolites were identified: three were associated with higher MIND adherence (3-hydroxyhippuric acid, 5-hydroxyindole-3-acetic acid, betaine - phenolic acids and amino acid related to plant foods) and five with lower MIND adherence (1-methylhistidine from red meat; cyclo(L-leucyl-L-prolyl) from coffee; tartaric acid from wine; myristoyl-carnitine and dehydroepiandrosterone sulfate, endogenous). The French-MIND metaboscore was linked to lower odds of cognitive decline, although replication was not statistically significant after multivariable adjustment.

conclusionA novel metabolomic signature of the MIND diet was characterized, which may help screen older adults at risk of poor brain nutrition and could support personalized dietary prevention strategies.

Indexed as

Cognitive declineDietMetabolomicsMIND diet

Identifiers

PMID42731173
PMCPMC13586864

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