Evidence map›Paper›PMID 42731120›Full record

ArticleExperimental physiology2026

Thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor.

Lauren J Clayton, Jo Corbett, Anthony I Shepherd, Heather Massey, Don S Urquhart, Neil Maxwell, Gary Connett, Mark Allenby, Julian Legg, Thomas Daniels and 1 more

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lauren J ClaytonClinical, Health and Rehabilitation Research Team, School of Psychology, Sport and Health Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Jo CorbettExtreme Environments and Occupational Performance Research Group, School of Psychology, Sport and Health Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.ORCID https://orcid.org/0000-0002-6552-6471
Anthony I ShepherdClinical, Health and Rehabilitation Research Team, School of Psychology, Sport and Health Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.ORCID https://orcid.org/0000-0001-6392-7944
Heather MasseyClinical, Health and Rehabilitation Research Team, School of Psychology, Sport and Health Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.ORCID https://orcid.org/0000-0002-7542-513X
Don S UrquhartDepartment of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, Scotland, UK.
Neil MaxwellEnvironmental Extremes Laboratory, University of Brighton, Eastbourne, UK.
Gary ConnettUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.ORCID https://orcid.org/0000-0003-1310-3239
Mark AllenbyUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Julian LeggUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Thomas DanielsUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Zoe L SaynorUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.ORCID https://orcid.org/0000-0003-0674-8477

Funding

Cystic Fibrosis Warriors Charity 1178063
6 · The paper itself

Abstract

The objective of this study was to investigate thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis (pwCF) on Elexacaftor/Tezacaftor/Ivacaftor (ETI) versus healthy controls, and to explore their lived experiences of heat stress. This mixed-methods, multi-study project comprised: (i) a laboratory study where pwCF (n = 6) and matched controls (n = 6) completed two 30 minutes cycling bouts in the heat (35°C, 30% relative humidity), at 150 and 250 W·m

Indexed as

exertional heat illnessheat stressrespiratory diseasethermal physiology

Identifiers

PMID42731120
PMCPMC13570782

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.