Sentinel Node Navigation Surgery for Upper Gastrointestinal Malignancies: Current Status, Clinical Significance, and Future Perspectives.

Yoshihiro Hiramatsu, Eisuke Booka, Hirotoshi Kikuchi, Hiroya Takeuchi

Abstract readReview

In one paragraph

Review in Magyar onkologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoshihiro HiramatsuSchool of Medicine, Hamamatsu University, Department of Surgery, Hamamatsu, Japan. takeuchi@hama-med.ac.jp.

Eisuke BookaSchool of Medicine, Hamamatsu University, Department of Surgery, Hamamatsu, Japan. takeuchi@hama-med.ac.jp.

Hirotoshi KikuchiSchool of Medicine, Hamamatsu University, Department of Surgery, Hamamatsu, Japan. takeuchi@hama-med.ac.jp.

Hiroya TakeuchiSchool of Medicine, Hamamatsu University, Department of Surgery, Hamamatsu, Japan. takeuchi@hama-med.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo review the current evidence, technical considerations, clinical significance, and future perspectives of sentinel node navigation surgery (SNNS) for upper gastrointestinal malignancies, focusing on gastric and esophageal cancers.

methodsThis narrative review summarizes evidence on sentinel node (SN) mapping, biopsy, and SNNS in gastric and esophageal cancers, focusing on feasibility, diagnostic accuracy, indications, and limitations.

resultsIn early gastric cancer, accumulating evidence supports the feasibility and diagnostic accuracy of SN mapping and biopsy, supporting SNNS as a promising platform for function-preserving gastric surgery. In esophageal cancer, clinical application remains challenging because of multidirectional lymphatic drainage and aggressive tumor biology; however, radioisotope-guided SN mapping has shown encouraging results in selected patients with early-stage disease.

conclusionsSNNS may reduce surgical invasiveness while preserving oncologic safety and postoperative function in selected patients with upper gastrointestinal malignancies. However, further validation and standardization are required before broader clinical implementation.

Indexed as

Esophageal NeoplasmsSentinel Lymph NodeSentinel Lymph Node BiopsyStomach NeoplasmsHumansLymphatic MetastasisLymph Node ExcisionNeoplasm Staging

Identifiers

PMID42731004

PMCPMC13577719

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.