Amphora Coffeaeformis Extract as a Novel Therapeutic Agent against Gamma Radiation-Induced Infertility in Male Rats.

Shady A Elfouly, Noha Sayed Hamed, Mohsen S Asker, Eman A Elmansy, Manal G Mahmoud, Amal I Hassan

Abstract read

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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Shady A ElfoulyRadioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID http://orcid.org/0000-0001-9908-3093

Noha Sayed HamedRadioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. noha.sayed@eaea.org.eg.ORCID http://orcid.org/0000-0001-7607-176X

Mohsen S AskerMicrobial Biotechnology Department, National Research Centre, 33 Bohouth Street, Dokki, Giza, 12311, Egypt.ORCID http://orcid.org/0000-0003-4321-0625

Eman A ElmansyMicrobial Biotechnology Department, National Research Centre, 33 Bohouth Street, Dokki, Giza, 12311, Egypt.ORCID http://orcid.org/0000-0001-5710-6752

Manal G MahmoudMicrobial Biotechnology Department, National Research Centre, 33 Bohouth Street, Dokki, Giza, 12311, Egypt.ORCID http://orcid.org/0000-0003-0376-2089

Amal I HassanRadioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID http://orcid.org/0000-0002-3760-1235

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gamma irradiation is a well-established environmental and therapeutic hazard known to impair male reproductive function through oxidative stress, hormonal disruption, and structural damage to testicular tissue. Natural antioxidants have emerged as potential protective agents against such effects. This study aimed to evaluate the protective and therapeutic efficacy of the algal extract of Amphora Coffeaeformis (ACE) after studying its initial composition, and, since it is a well-defined extract with a special structure and rich in biologically active compounds, in mitigating gamma radiation-induced reproductive toxicity in male Wistar rats. HPLC analysis was used to assess the monosaccharide components of ACE. In contrast, spectrophotometric analysis was used to evaluate the phenolic compounds and flavonoids. Analysis of the ACE revealed six different types of important monosugars, while the amount of phenolic compounds (TPC) and flavonoids (TFC) amounted to 370.5 mg/100 g (as gallic acid), and the total flavonoids amounted to 32.8 mg/100 g (as quercetin). The ACE radical-scavenging activity against DPPH was considerable and dose-dependent, reaching 85.00 ± 0.84% at a concentration of 2.5 mg/ml with IC

Indexed as

Amphora coffeaeformisAntioxidantsGamma radiationMale infertilityOxidative stressSperm analysis

Identifiers

PMID42730955

DOI10.3390/stresses5010022

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.