ArticleExperimental physiology2026
Protective effect of cannabinoid type 2 receptor agonist (JWH-133) against hepatotoxicity induced by Prangos ferulacea Lindl. extract.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Protective effect of cannabinoid type 2 receptor agonist (JWH-133) against hepatotoxicity induced by Prangos ferulacea Lindl. extract.Experimental physiology · 2026Article
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8 authors.
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Abstract
This study investigated Prangos ferulacea (PF)-induced hepatotoxicity, its potential association with endoplasmic reticulum (ER) stress and proinflammatory cytokines, and the effect of the cannabinoid type 2 receptor agonist JWH-133. Rats (n = 37) were divided into four groups: control-sham group (CSG, n = 9), PF extract group (PG, n = 9), PF extract + JWH-133 group (PJG, n = 9) and JWH-133 group (JG, n = 10). Hepatic ER stress markers (CHOP, GRP78 and ATF4), interleukin (IL)-17, IL-23, heat shock protein 72 (HSP72), and calpain, as well as serum IL-17, IL-23, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein and albumin, were assessed. Liver histology was evaluated using haematoxylin-eosin staining, and apoptosis was assessed by caspase-3 immunohistochemistry. No significant between-group differences were observed in hepatic GRP78, CHOP, ATF4, IL-17 or IL-23 levels. Similarly, serum IL-17 and IL-23 levels did not differ significantly among the groups. Calpain levels differed significantly among the groups (P = 0.0017), with higher levels in PG (P = 0.0325) and PJG (P = 0.0076) than in CSG. Compared with CSG, PG and PJG showed lower ALT (P = 0.0021 for both), AST (P = 0.0021 for both), albumin (P = 0.0031 and P = 0.0016, respectively) and total protein (P = 0.0056 and P = 0.0017, respectively) levels. Histopathological damage was significantly greater in PG than in CSG, PJG and JG (all P < 0.0001). Caspase-3 immunoreactivity was intense in PG and limited in PJG. PF extract caused marked liver injury without clear canonical ER stress activation. JWH-133 attenuated histopathological damage, consistent with the potential role of CB2 receptor activation. These findings support ER stress-independent mechanisms and warrant further investigation of CB2 activation as a hepatoprotective strategy.
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