ArticleSports medicine (Auckland, N.Z.)2026
Effects of Clenbuterol on Body Composition and Strength Following Resistance Training, Detraining, and Retraining in Healthy Adults: A Randomized Controlled Trial.
Article in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05692856 (Muscle Memory After Treatment With Anabolic Substance Clenbuterol and Resistance Training in Humans), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Memory After Treatment With Anabolic Substance Clenbuterol and Resistance Training in Humans: Myonuclear Addition, Hypertrophy and Myocellular Reprogramming
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundClenbuterol, a potent β
objectiveThe aim of the study was to investigate the effects of clenbuterol on body composition and strength during a resistance training intervention, as well as the long-term effects of prior use of clenbuterol during detraining and subsequent retraining in healthy young men and women.
methodsThis randomized, double-blinded, placebo-controlled trial was conducted at the University of Copenhagen, Denmark, between March 2023 and March 2025. Thirty-two healthy men (26 ± 3 years; mean ± SD; n = 16) and women (25 ± 5 years; n = 16) completed 8 weeks of resistance training with daily ingestion of clenbuterol (80 μg) (n = 16) or placebo (n = 16). This was followed by 16 weeks of detraining and another 8 weeks of resistance training. Before the intervention and after each training and detraining period, body composition was assessed by dual-energy X-ray absorptiometry (DXA) and strength was assessed by leg press and bench press 1-repetition maximum (1RM).
resultsClenbuterol increased gains in lean mass (+ 1.7 kg, p < 0.001) and 1RM bench press (+ 6 kg, p < 0.001) and leg press (+ 16 kg, p = 0.001) during 8 weeks of resistance training compared with placebo, with a more pronounced effect in males than females (lean mass: p = 0.003; 1RM bench press: p < 0.001), whereas the decrease in fat mass did not differ between clenbuterol and placebo (p = 0.614). Following cessation of clenbuterol, detraining decreased lean mass (p < 0.001), 1RM bench press (p < 0.001), and 1RM leg press (p = 0.026) to a greater extent in the clenbuterol group, such that initial changes in lean mass (p = 0.363) and 1RM bench press (p = 0.834) no longer differed from placebo, whereas 1RM leg press remained elevated in the clenbuterol group (p = 0.041). Retraining increased lean mass and 1RM leg press with no differences between the clenbuterol and placebo group (lean mass: p = 0.393; 1RM leg press: p = 0.662), whereas the increase in 1RM bench press was greater in the clenbuterol group (+ 3 kg, p = 0.047).
conclusionClenbuterol markedly augments training-induced gains in lean mass and strength. After discontinuation, prior clenbuterol exposure does not enhance retraining-induced lean mass gains, but some strength-related advantages persist.
trial registrationClinicalTrials.gov identifier, NCT05692856.
Identifiers
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Registered trials
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