ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Caregivers' proxy assessments of health-related quality of life in patients with hematologic malignancies.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivePatients with hematologic malignancies are commonly burdened by the disease itself as well as treatment-related side effects, which makes it difficult for them to complete the health-related quality of life (HRQoL) assessments. We aimed to investigate the reliability and influencing factors of caregivers as proxies in measuring HRQoL for patients with hematologic malignancies.
methodsA total of 203 patients with hematologic malignancies and their caregivers were enrolled. Both patients and caregivers independently completed the EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) questionnaire to collect patient self-rated HRQoL and caregiver proxy-rated HRQoL. Additionally, caregivers completed the Generalized Anxiety Disorder 7-Item Scale, Patient Health Questionnaire-9, and Family APGAR Index to evaluate their anxiety symptoms, depression symptoms, and perceptions of family functioning.
resultsThe caregiver proxy-rated HRQoL exhibited strong correlations with patient self-rated HRQoL, in both EQ-5D-5L utility scores (r = 0.679, P < 0.001) and EQ-5D-5L dimensions (correlation coefficients from 0.518 to 0.695, all P < 0.001). The agreement between caregiver proxy-rated and patient self-rated EQ-5D-5L utility scores was good (ICC = 0.730, 95% CI 0.658-0.788). Exact agreement between caregiver proxy ratings and patient self-ratings ranged from 66.5% to 84.2% across EQ-5D-5L dimensions. Greater anxiety symptoms (r = 0.408, P < 0.001) or depression symptoms (r = 0.288, P < 0.001) among caregivers were significantly associated with their overestimation of patients' symptom burden.
conclusionCaregivers may be reliable proxies for assessing HRQoL in patients with hematologic malignancies. However, the anxiety or depression symptoms of caregivers may increase their overestimation in patients' symptom burden.
Indexed as
Identifiers
42730812What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.