Observational studyJournal of cellular and molecular medicine2026
Mechanism of Gu-Ben-Hua-Shi (AESS) Formula Regulating Autophagy Through Hippo-YAP Pathway in Restoring the Skin Barrier in Atopic Dermatitis.
Xin Ma, Yiting Huang, Xiao Lv, Xiumei Mo, Junfeng Liu, Fenggen Yan, Siqi Ye, Yu Zhang, Dacan Chen, Jinjing Jia
Abstract readObservational Study
In one paragraphObservational study in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Xin MaState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.ORCID https://orcid.org/0009-0003-9472-2660 Yiting HuangState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.ORCID https://orcid.org/0009-0000-1610-7759 Xiao LvState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiumei MoState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Junfeng LiuState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Fenggen YanState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.ORCID https://orcid.org/0000-0001-5832-6597 Siqi YeState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yu ZhangState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Dacan ChenState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Jinjing JiaState Key Laboratory of Traditional Chinese Medicine Syndrome/State Key Laboratory of Dampness Syndrome of Chinese Medicine/Department of Dermatology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.ORCID https://orcid.org/0000-0003-2297-4394 Funding
Guangdong Provincial Key Laboratory of Chinese Medicine for prevention and treatment of Refractory Chronic Disease 2023KT15528Guangzhou Basic and Applied Basic Research Foundation 2024A03J0547Guangzhou Basic and Applied Basic Research Foundation 2025A03J4063National Natural Science Foundation of China 82274521Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine 20254057State Key Laboratory of Traditional Chinese Medicine Syndrome Member Project QZ2025ZZ24the Research Fund for Qingmiao Talents of Guangdong Provincial Hospital of Chinese Medicine SZ2024QN04
6 · The paper itselfAbstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and immune balance disorders. Currently, drugs for repairing the skin barrier in AD are limited. The gu-ben-hua-shi formula (AESS) has been shown to regulate Th1/Th2/Th17/Treg imbalance with good clinical effect. However, its effects on regulating autophagy, repairing the skin barrier, and interacting with Yes-associated protein (YAP) remain unknown. To elucidate the therapeutic effects of AESS on AD and to investigate its mechanism of restoring skin barrier function through the Hippo-YAP pathway. We conducted a single-arm observational study to evaluate the clinical efficacy of the AESS in patients with AD. Network pharmacology was used to predict the potential therapeutic targets and mechanisms. AD mouse models were established by house dust mite stimulation in Nishiki-nezumi Cinnamon/Nagoya mice, and the effects on autophagy and the skin barrier were measured using western blotting, immunofluorescence, mRFP-GFP-LC3 tandem fluorescence assay, and transmission electron microscopy. The effects of AESS serum on an AD-like inflammatory cell model were detected in HaCaT cells stimulated with interferon-γ (IFN-γ)/tumour necrosis factor-α (TNF-α). Activity of the Hippo-YAP signalling pathway was also investigated after YAP knockdown. AESS improved skin rash and barrier function, reduced eosinophil counts, and increased Th1/Th2 and Treg/Th17 ratios in patients with AD. AESS increased autophagy, improved skin barrier function, and inhibited Hippo-YAP signalling pathway activity. YAP knockdown reduces these therapeutic effects. Besides regulating immune imbalance, AESS increases keratinocyte autophagy levels, thereby restoring skin barrier function in AD through the Hippo-YAP signalling pathway. Trial Registration: The Chinese clinical trial registration website: ITMCTR202500042.
Indexed as
AutophagyDermatitis, AtopicDrugs, Chinese HerbalProtein Serine-Threonine KinasesSkinTranscription FactorsAdaptor Proteins, Signal TransducingAdolescentAdultAnimalsChildDisease Models, AnimalFemaleHippo Signaling PathwayHumansKeratinocytesAdaptor Proteins, Signal TransducingDrugs, Chinese HerbalProtein Serine-Threonine KinasesTranscription FactorsYAP-Signaling Proteinsatopic dermatitisautophagyChinese herbal medicineskin barriertraditional Chinese medicineyes‐associated protein
Identifiers
PMID42730570
PMCPMC13570263
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