ArticleCardiology research2026
Takotsubo Syndrome: Clinical and Diagnostic Characteristics of 26 Consecutively Hospitalized Patients Over a Five-Year Period.
Article in Cardiology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Takotsubo syndrome (TTS) is a transient form of acute heart failure characterized by reversible left ventricular (LV) dysfunction, predominantly affecting postmenopausal women following emotional or physical stress. Despite its historically benign reputation, in-hospital complications and mortality remain clinically significant. Data from Central and Eastern European populations are underrepresented in large international registries. The study aimed to describe the clinical, echocardiographic, and biochemical characteristics of a consecutive cohort of 26 patients hospitalized with TTS over a 5-year period and to compare findings with published international registry data. Methods: This is a retrospective observational study (case series) of 26 consecutive patients. Diagnosis was established per Mayo Clinic criteria (2008). Descriptive statistics and Pearson correlation analysis were applied. Results: The cohort comprised 23 women (88.5%) and three men (11.5%), with a mean age of 71.4 ± 12.0 years. A triggering event was identified in all 26 patients (100%). Mean initial left ventricular ejection fraction (LVEF) was 41.8±11.4%; classic apical ballooning was present in 100%. N-terminal pro-B-type natriuretic peptide (NT-proBNP) showed a moderate inverse correlation with LVEF (ρ = -0.53, Spearman). Mean length of hospital stay was 12.1 ± 10.2 days (median 7). In-hospital complications occurred in 25% of survivors; in-hospital mortality was 7.7% (2/26). Conclusions: This study is consistent with the predominance of TTS in elderly women with universal triggering events and significant systolic dysfunction at presentation. NT-proBNP showed an inverse correlation with LVEF, reflecting neurohumoral activation proportional to hemodynamic impairment. Mortality and complication rates were at the upper limit of published values. These hypothesis-generating findings support the need for prospective multicenter validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.