ArticleWorld journal of oncology2026
Phosphatase of Regenerating Liver-3 Expression Correlates With PTENP1/miR-21 and miR-17/PTEN Dysregulation in Endometrial Adenocarcinoma Progression.
Article in World journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Endometrial cancer is a prevalent gynecologic malignancy, which is predominantly of the histological type known as endometrial adenocarcinoma. Deletion of the tumor suppressor gene Methods: Following the modulation of specific molecule expression, the levels of relevant molecules were assessed by quantitative real-time polymerase chain (qRT-PCR) and Western blot. Endometrial adenocarcinoma cell proliferation and migration were further determined by Cell Counting Kit-8 (CCK-8) assay and scratch assay. Results: PTEN and phosphatase and tensin homolog pseudogene 1 (PTENP1) expression in endometrial adenocarcinoma samples and cell lines was analyzed and found to be closely associated with the malignant biological behavior of tumors. High expressions of PTENP1 and PTEN inhibited the proliferative and migratory capacities of endometrial adenocarcinoma cells, and high expressions of PRL-3, miR-21 and miR-17 enhanced their proliferative and migratory capacities. Bioinformatics analysis predicted that PTEN and PTENP1 were direct targets of miR-21 and miR-17. PRL-3 could downregulate PTENP1 and PTEN through upregulation of miR-21 and miR-17, which in turn could enhance the proliferative and migratory capacities of endometrial adenocarcinoma. Conclusions: PRL-3 may play a pivotal role in promoting the proliferation and migration of endometrial adenocarcinoma by affecting the PTENP1/miR-21 or miR-17/PTEN.
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