ArticleReproductive medicine and biology
Efficacy of Hyaluronan-Enriched Transfer Medium in Frozen-Thawed Embryo Transfer: A Retrospective Single-Center University Hospital Study Using a Historical Cohort.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Objective: Since 2023, our university hospital has incorporated hyaluronan-enriched transfer medium (HETM) into all frozen-thawed embryo transfers (FETs). This study aimed to evaluate whether HETM improved clinical pregnancy rates in FET, particularly in patients with recurrent implantation failure (RIF). Methods: We analyzed 368 FET cycles using a conventional hyaluronan-free transfer medium and 358 FET cycles using HETM, in which thawed embryos were incubated for 2-4 h before transfer. The main outcome was clinical pregnancy. Multiple logistic regression was used to evaluate the effectiveness of HETM. Results: The mean age of patients was 37.4 years (standard deviation = 4.2), and RIF, defined as failure to achieve pregnancy after two or more previous embryo transfers, accounted for 51.2%. Clinical pregnancy rates were significantly higher in the HETM group (37.7%) than in the control group (27.2%) ( Conclusion: This study demonstrates HETM use is associated with improved clinical pregnancy rates in FET, particularly in cases of RIF.
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