ArticleMediterranean journal of hematology and infectious diseases2026
Association of Baseline Platelet Count with Complete Remission, Severe Bleeding, and 24-Month Overall Survival in Patients with Newly Diagnosed Acute Myeloid Leukemia: A Multi-Center Retrospective Cohort Study.
Article in Mediterranean journal of hematology and infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the association between baseline platelet count at diagnosis and complete remission (CR) rate, severe bleeding during induction, and overall survival (OS) in newly diagnosed acute myeloid leukemia (AML). Methods: This multi-center retrospective cohort study enrolled 356 non-acute promyelocytic leukemia (non-APL) AML patients treated with first-line therapy between January 2020 and December 2025. Patients were classified as having a low baseline platelet count (<50 × 10 Results: CR (53.7% vs. 50.7%, P=0.665) and CR/CRi rates (63.3% vs. 68.8%, P=0.339) did not differ significantly between groups. After excluding patients with bleeding at diagnosis, low baseline platelet count was not independently associated with severe bleeding in the primary Firth logistic analysis (OR=1.761, 95% CI 0.631-5.583, P=0.287; 20 events in 231 patients), although the association remained in the full-cohort sensitivity analysis (adjusted OR=2.753, 95% CI 1.318-5.749, P=0.007). Kaplan-Meier analysis showed lower 24-month OS in the low-platelet group (58.2% vs. 77.8%; log-rank P<0.001), and the adjusted 24-month Cox model yielded an HR of 1.811 (95% CI 1.145-2.864, P=0.011). The association persisted after additional adjustment for participating center (HR=1.896, 95% CI 1.192-3.017, P=0.007). Per 10 × 10 Conclusion: A baseline platelet count <50 × 10
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