Evidence map›Paper›PMID 42730325›Full record

ArticleFrontiers in nutrition2026

Randa Mlik, Mohamed Amine Fares, Nour Elhouda Mekhadmi, Asma Abid, Assia Bentahar, Walid Boussebaa, Slimane Ahmed Benmchih Ayada, Mohamed Kharsi, Makhlouf Sekour, Samia Hamouda and 6 more

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Randa MlikHigher School of Saharan Agriculture, El Oued, Algeria.
Mohamed Amine FaresHigher School of Saharan Agriculture, El Oued, Algeria.
Nour Elhouda MekhadmiLaboratory of the Development and Technology of Saharan Resources (VTRS), University of El Oued, El Oued, Algeria.
Asma AbidLaboratory of Valorization and Promotion of Saharan Resources (VPRS), Faculty of Mathematics and Matter Sciences, University of Ouargla, Ouargla, Algeria.
Assia BentaharLaboratory of Phytotherapy Applied to Chronic Diseases, SNV Faculty, University of Setif, Setif, Algeria.
Walid BoussebaaScientific and Technical Research Center in Physico-Chemical Analysis (CRAPC), Headquarters Ex-Pasna Industrial Zone, Bou-Ismail, Tipaza, Algeria.
Slimane Ahmed Benmchih AyadaNational Institute of Agronomic Research of Algeria, Station of Adrar, Adrar, Algeria.
Mohamed KharsiNational Institute of Agronomic Research of Algeria, Station of Adrar, Adrar, Algeria.
Makhlouf SekourDepartment of Agronomic Sciences, Faculty of Life and Natural Sciences, Kasdi-Merbah University, Ouargla, Algeria.
Samia HamoudaAnesthesiology and ICU Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Wafa Ali EltaybBiotechnology Department, Faculty of Science and Technology, Shendi University, Shendi, Sudan.
Han YuPediatric Research Institute, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Mohnad AbdallaPediatric Research Institute, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Ali AlsalmeDepartment of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mikhael BechelanyInstitut Européen des Membranes, IEM, UMR 5635, University Montpellier, ENSCM, CNRS, Montpellier, France.
Ahmed BarhoumSchool of Chemical and BioPharmaceutical Sciences, Technological University Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antioxidant-rich plant-derived compounds are increasingly investigated for their role in preventing oxidative stress and managing metabolic disorders. Methods: This study aimed to evaluate the phytochemical composition and nutraceutical potential of Results: The ethanolic extract was characterized using UPLC-ESI-MS/MS, revealing a diverse phytochemical profile comprising flavonoids and phenolic acids, with major constituents including curcumin, beta-carotene, and myricetin derivatives. The extract exhibited notable antioxidant activity, with 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (IC50 = 0.0706 ± 0.006 mg/mL) and hydrogen peroxide scavenging (IC50 = 0.1789 ± 0.083 mg/mL), alongside moderate metal-chelating capacity. The extract exhibited significant in vitro alpha-amylase inhibitory activity. Molecular docking and 300 ns molecular dynamics simulations further suggested that myricetin 3-arabinoside may contribute to the observed inhibitory effect through stable interactions with the catalytic pocket of human pancreatic alpha-amylase. In addition, the extract showed antimicrobial activity, indicating its potential for applications related to food safety and preservation. Discussion: However, the predominant nutritional relevance lies in its high polyphenol content and associated antioxidant and enzyme-inhibitory properties. Overall, these findings suggested that

Indexed as

Centaurea pungensfunctional foodmetabolic healthnutraceuticalpolyphenolsα-amylase inhibition

Identifiers

PMID42730325
PMCPMC13564923

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.