Evidence map›Paper›PMID 42730309›Full record

ArticleACS nano medicine2026

Immunization with Virus-Like Particles Displaying Ara h 2‑Derived Peptides to Mitigate Peanut Allergy.

Johanna M Smeekens, Matthew C Jenkins, Kahlia Carl, Jessica R Humphrey, Andrew V Turner, James W Krempski, Soheila J Maleki, Ananda R Podilapu, Brian P Vickery, M G Finn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Johanna M SmeekensDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States.ORCID https://orcid.org/0000-0001-9651-3852
Matthew C JenkinsSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID https://orcid.org/0000-0002-0583-3533
Kahlia CarlSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Jessica R HumphreyDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Andrew V TurnerDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
James W KrempskiDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Soheila J MalekiAgricultural Research Service, Southern Regional Research Center, United States Department of Agriculture, New Orleans, Louisiana 70124, United States.ORCID https://orcid.org/0000-0002-6056-9958
Ananda R PodilapuSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Brian P VickeryDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
M G FinnSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID https://orcid.org/0000-0001-8247-3108
Michael D KulisDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States.

Funding

TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Virus-Like Particle Based Immunization Against Peanut AllergyR21AI166639 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI FINN, M.G. · 2021 to 2022
$450k
NIAID NIH HHS R21 AI166639NIEHS NIH HHS T32 ES007126
6 · The paper itself

Abstract

Peanut allergy is caused by aberrant IgE-driven immune responses to a well-defined set of peptide sequences within allergenic proteins. Oral and sublingual desensitization therapies are associated with the elicitation of IgG antibodies against allergenic proteins that interfere with IgE-induced effects. We tested whether inducing peptide-specific IgG responses by displaying key epitopes on immunogenic protein nanoparticle platforms protected against peanut allergy. A panel of 10 IgE epitopes from Ara h 2, the major degranulation-inducing peanut allergen, were displayed on two virus-like particles (VLPs): modified versions of both the bacteriophage PP7 coat protein and the iron-regulating encapsulin nanocompartment of the soil bacterium

Indexed as

allergy immunotherapyAra h 2encapsulin (Enc)food allergypeanut allergyvirus-like particle (VLP)

Identifiers

PMID42730309
PMCPMC13564887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.