Evidence map›Paper›PMID 42730290›Full record

ArticlePeerJ2026

Sphingosine 1-phosphate signalling contributes to transforming growth factor-β1-induced myofibroblast differentiation in oral cancer.

Kathyleen Hui Lin Chong, Wee Lin Wong, Deron R Herr, Wai-Leng Lee, Lee Fah Yap, Ian C Paterson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kathyleen Hui Lin ChongDepartment of Oral and Craniofacial Sciences, Universiti Malaya, Kuala Lumpur, Malaysia.
Wee Lin WongDepartment of Oral and Craniofacial Sciences, Universiti Malaya, Kuala Lumpur, Malaysia.
Deron R HerrSchool of Medicine, Indiana University, Terre Haute, Indiana, United States.
Wai-Leng LeeSchool of Science, Monash University, Kuala Lumpur, Malaysia.
Lee Fah YapDepartment of Oral and Craniofacial Sciences, Universiti Malaya, Kuala Lumpur, Malaysia.
Ian C PatersonDepartment of Oral and Craniofacial Sciences, Universiti Malaya, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognosis for patients with oral squamous cell carcinoma (OSCC) is poor and novel ways to manage the disease are required. The density of myofibroblastic cancer-associated fibroblasts (myoCAFs) within the OSCC stroma correlates with poor prognosis, suggesting that myoCAFs could be targetted therapeutically. OSCC cells have been shown to regulate myoCAF differentiation

Indexed as

Carcinoma, Squamous CellCell DifferentiationLysophospholipidsMouth NeoplasmsMyofibroblastsSphingosineTransforming Growth Factor beta1ActinsCell Line, TumorCulture Media, ConditionedHumansPhosphotransferases (Alcohol Group Acceptor)Receptors, LysosphingolipidSignal TransductionSphingosine-1-Phosphate ReceptorsSphingosine KinaseACTA2 protein, humanActinsCulture Media, ConditionedLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)Receptors, LysosphingolipidS1PR2 protein, humanSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsSphingosine KinaseTGFB1 protein, humanTransforming Growth Factor beta1CAFFibroblastMyofibroblastOral cancerSphingosine 1-phosphateTGF-beta

Identifiers

PMID42730290
PMCPMC13564403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.