Evidence map›Paper›PMID 42730243›Full record

ArticleGynecologic oncology reports2026

Markedly elevated alpha-fetoprotein leading to the diagnosis of high-grade endometrial carcinoma during hepatocellular carcinoma surveillance.

Jayati Anand, Alicia Youssef, Lawrence Hsu Lin, Niloofar O Karbasian, Annekathryn Goodman, Michelle Lai

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jayati AnandBeth Israel Deaconess Medical Center, Department of Internal Medicine; 330 Brookline Avenue, Boston, MA 02215, United States.
Alicia YoussefMassachusetts General Hospital, Division of Gynecologic Oncology, 55 Fruit Street Boston, MA 02114, United States.
Lawrence Hsu LinMassachusetts General Hospital, Department of Pathology, 55 Fruit Street Boston, MA 02114, United States.
Niloofar O KarbasianMassachusetts General Hospital, Department of Radiology, 55 Fruit Street Boston, MA 02114, United States.
Annekathryn GoodmanMassachusetts General Hospital, Division of Gynecologic Oncology, 55 Fruit Street Boston, MA 02114, United States.
Michelle LaiBeth Israel Deaconess Medical Center, Department of Gastroenterology and Hepatology, 330 Brookline Avenue, Boston, MA 02215, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alpha-fetoprotein (AFP) is widely used for hepatocellular carcinoma surveillance in patients with chronic liver disease. AFP is rarely elevated in endometrial cancer but may be a useful marker of aggressive histologic variants. Case: A 70-year-old woman with autoimmune hepatitis-associated cirrhosis undergoing hepatocellular carcinoma (HCC) surveillance developed a rapid rise in AFP from 5 ng/mL to greater than 13,000 ng/mL. Liver imaging revealed no evidence of HCC. Positron-emission tomography (PET) demonstrated focal uptake in the uterus. Pelvic magnetic resonance imaging identified a deeply invasive endometrial mass. Hysteroscopic biopsy revealed high-grade endometrial carcinoma. The patient subsequently underwent total laparoscopic hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO) with pathology demonstrating a stage IB high-grade endometrial carcinoma with extensive somatic-type glandular yolk sac / fetal-type differentiation and minor carcinosarcoma component (<5%). Serum AFP steadily and rapidly decreased after surgery. Conclusion: This case highlights the importance of considering extrahepatic sources of AFP elevation and demonstrates an unusual presentation of endometrial carcinoma detected during HCC surveillance.

Indexed as

Alpha-fetoproteinCase reportCirrhosisEndometrial carcinomaTumor markers

Identifiers

PMID42730243
PMCPMC13564056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.