ArticleFrontiers in pharmacology2026
A multi-omics integrative analyses reveals
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Background: Methods: We identify bioinformatic screening and Mendelian randomization (MR) on 760 candidate berberine-related genes; 315 with adequate instruments underwent MR for causal links to DLBCL. Follow-up analyses included pathway enrichment, Protein-Protein Interaction (PPI) networks, machine-learning prognostic modeling, molecular docking and dynamics, single-cell RNA sequencing, cell-cell communication inference, bulk transcriptomic validation, and Results: MR identified several berberine-related genes with putative causal associations with DLBCL. Conclusion: This integrative study identifies berberine-related genes with potential causal relevance to DLBCL and prioritizes CYBB as a functionally relevant target linked to apoptosis, immune regulation, and prognosis, highlighting the potential involvement of berberine-
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