ReviewAsia-Pacific journal of oncology nursing2026
Effects of eHealth interventions on depression, anxiety, quality of life, and post-traumatic stress symptoms among parents of children with cancer: A meta-analysis of randomized controlled trials.
Review in Asia-Pacific journal of oncology nursing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
Objective: To synthesize evidence from randomized controlled trials on the effects of eHealth interventions on depression, anxiety, quality of life, and post-traumatic stress symptoms in parents of children with cancer. Methods: PubMed, Embase, the Cochrane Central Register of Controlled Trials, CINAHL, PsycINFO, Web of Science, CNKI, VIP, and SinoMed were searched from inception to 31 January 2026. Two reviewers independently screened studies, extracted data, assessed risk of bias using RoB 2 and rated certainty of evidence using Grading of Recommendations Assessment, Development and Evaluation (GRADE). For family-randomized trials, standard errors were inflated using a design effect with a primary intraclass correlation coefficient (ICC) of 0.50; sensitivity analyses used ICCs of 0.10, 0.25, and 0.75. Exploratory subgroup analyses, sensitivity analyses, and publication bias assessments were conducted when appropriate. Results: Thirteen randomized controlled trials involving 1022 parents were included in the meta-analysis. eHealth interventions significantly reduced depression (standardized mean difference [SMD] = -0.56, 95% confidence interval [CI] -0.76 to -0.36) and anxiety (SMD = -0.66, 95% CI -1.12 to -0.20). The effect on quality of life was not statistically significant (SMD = 0.36, 95% CI -0.06 to 0.78). A significant reduction in post-traumatic stress symptoms was observed (SMD = -0.48, 95% CI -0.84 to -0.11), but this result was not stable in sensitivity analysis. For anxiety, excluding one influential study reduced the pooled effect to -0.45 (95% CI -0.62 to -0.27) and Conclusions: eHealth interventions may help reduce depression in parents of children with cancer. Evidence for anxiety, quality of life and post-traumatic stress symptoms remains limited and should be interpreted with caution. More rigorous randomized controlled trials with clearer intervention reporting, longer follow-up, and better adherence data are needed. Systematic review registration: CRD420251236158.
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