Evidence map›Paper›PMID 42730095›Full record

ArticleJournal of hazardous materials advances2026

Comprehensive profiling of metal compound toxicity: potential novel targets and mechanistic insights using Tox21 screening.

Masato Ooka, Precious Adesina, Vishakha Goyal, Jinghua Zhao, Shuaizhang Li, Gabrielle Feldman, Charlotte TeKrony, Dvir Blivis, Majid Harouni, Matthew D Hall and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hazardous materials advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Masato OokaNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Precious AdesinaNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Vishakha GoyalNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Jinghua ZhaoNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Shuaizhang LiNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Gabrielle FeldmanNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Charlotte TeKronyNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Dvir BlivisNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Majid HarouniNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Matthew D HallNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Stephen S FergusonDivision of the Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
David ReifDivision of the Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Ty VossNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Ruili HuangNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Menghang XiaNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Toxicology in the 21st Century Program (Tox21) - Systems ToxicologyZIATR000038 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI XIA, MENGHANG · 2015 to 2025
$5.7M
Intramural NIH HHS ZIA TR000038
6 · The paper itself

Abstract

Metals and metalloids are widely used in industrial applications, and increasing experimental and epidemiological evidence has linked metal exposure to adverse health outcomes. However, the underlying mechanisms for these effects have not been fully understood. As a part of the Toxicology in 21

Identifiers

PMID42730095
PMCPMC13567650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.