Evidence map›Paper›PMID 42730055›Full record

ArticleEuropean journal of anaesthesiology and intensive care2026

Low-concentration norepinephrine in the French operating theatre: A study of daily practices and pharmacological dosages in real-life conditions.

Manon Iraqi, Fabrice Vallée, Joaquim Mateo, Alexandre Mebazaa, Emmanuel Weiss, Juliette Oliary, Jacques Callebert, Jérome Cartailler, Jona Joachim

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Article in European journal of anaesthesiology and intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Manon IraqiFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Fabrice ValléeFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Joaquim MateoFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Alexandre MebazaaFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Emmanuel WeissFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Juliette OliaryFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Jacques CallebertFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Jérome CartaillerFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).
Jona JoachimFrom the Department of Anaesthesia and Critical Care, Lariboisière Hospital, APHP (MI, FV, JM, AM, JC, JJ), Université Paris Cité, Inserm UMRS 942 Mascot (FV, JM, AM, JC, JJ), Department of Anaesthesiology and Critical Care, Hôpital Beaujon, DMU PARABOL, AP-HP Nord and Université de Paris, Clichy, France (EW), Groupe hospitalo-universitaire AP-HP Nord-Université de Paris, Site Lariboisière, Pharmacie (JO), Département de Biochimie et de Biologie Moléculaire, AP-HP, Hôpital Lariboisière, Paris, France (JC).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraditionally, ephedrine and phenylephrine have been used to maintain blood pressure during anaesthesia. The use of low-concentration norepinephrine ('baby norepinephrine', bNOR) appears to be increasing.

objectivesTo better define the current role of norepinephrine in the management of intra-operative hypotension and to identify the challenges associated with its use.

designA practice survey (including collection of vasopressor usage data and a questionnaire on the use of bNOR in French operating rooms), combined with pharmacological assessments of norepinephrine dilutions.

settingVasopressor usage data were collected between 2017 and 2022 in 21 French hospitals. The survey was conducted from July 2021 to April 2022 among anaesthesia personnel within the French-speaking community. Pharmacological analyses were performed in two French university hospitals. PATIENTS: None.

interventionNone.

main outcome measuresTo assess vasopressor use in operating theatres in France, and to evaluate the accuracy and stability of manually prepared bNOR dilutions.

resultsUsage data demonstrated an increase in norepinephrine use from 28 518 to 59 598 vials (+92.4%), whereas phenylephrine use decreased over the same period from 49 407 vials and prefilled syringes to 14 252 (-71.1%). Survey findings indicated that a majority of respondents (72.5%) use bNOR diluted to concentrations of 10 and 16 μg ml

conclusionbNOR is emerging as a standard approach for the management of intra-operative hypotension in French operating theatres. However, dilution inaccuracies and stability limitations highlight the need for ready-to-use formulations in order to reduce errors and improve peri-operative care.

Identifiers

PMID42730055
PMCPMC13568125

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