Evidence map›Paper›PMID 42730032›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2026

Biphasic acclimation for simultaneous wide-field fluorescent Ca

Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M Strittmatter, Evelyn M R Lake

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Francesca MandinoDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.ORCID https://orcid.org/0000-0002-5605-0854
Taekyung KangDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States.ORCID https://orcid.org/0009-0005-3407-6710
Xilin ShenDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.
Corey HorienDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States.
Xenophon PapademetrisDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.ORCID https://orcid.org/0000-0001-7711-3335
Stephen M StrittmatterWu Tsai Institute, Yale University School of Medicine, New Haven, CT, United States.
Evelyn M R LakeDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.

Funding

Prion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6M
Multimodal imaging of prodromal synaptic, circuit, and network-level dysfunction in a murine model of Alzheimer's diseaseRF1NS130069 · NINDS · YALE UNIVERSITY · PI CAI, ZHENGXIN, LAKE, EVELYN MR · 2022 to 2022
$2.5M
Multimodal imaging of prodromal synaptic, circuit, and network-level dysfunction in a murine model of Alzheimer's diseaseR01NS130069 · NINDS · YALE UNIVERSITY · PI Zhengxin Cai, Evelyn MR Lake · 2025 to 2026
$1.7M
Educating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientistsR25MH119043 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Mariella De Biasi, MATTHEW S KAYSER · 2019 to 2026
$1.6M
NIA NIH HHS R01 AG034924NIMH NIH HHS R25 MH119043NINDS NIH HHS R01 NS130069NINDS NIH HHS RF1 NS130069
6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI) can be applied in mice and humans, making it a key technology in translational neuroimaging research. Yet, most fMRI studies in rodents use anesthesia to limit subject motion and stress. This puts a hard boundary on the range of brain and behavioral states that can be studied in animals, and deviates from the near-universal practice of imaging people while awake. Recent years have seen a push toward the development of acclimation protocols for performing fMRI in mice without anesthesia, but the results have been mixed. In parallel, imaging mice without anesthesia has become routine for complementary neuroimaging methods, including wide-field fluorescence calcium (WF-Ca

Indexed as

BrainCalciumMagnetic Resonance ImagingOptical ImagingWakefulnessAnimalsIsofluraneMaleMiceMice, Inbred C57BLOxygenCalciumIsofluraneOxygenawakeblood oxygen level-dependent signalbrain networksfluorescent calcium imagingfunctional connectivityfunctional magnetic resonance imagingmousemultimodal imagingwide-field imaging

Identifiers

PMID42730032
PMCPMC13563530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.