Evidence map›Paper›PMID 42729938›Full record

ArticleBioactive materials2027

A hydrogel ionic circuit electrical stimulation system to restore denervated muscle following long-gap peripheral nerve injury.

Olawale A Alimi, Mitchell Kuss, Sema G Kilic, Mengtao Sun, Amir Salati, Shibiao Wan, Christos Argyropoulos, Fan Zhao, Huiyin Tu, Han-Jun Wang and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Olawale A AlimiMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mitchell KussMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Sema G KilicDepartment of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Mengtao SunDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Amir SalatiMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Shibiao WanDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Christos ArgyropoulosDepartment of Electrical Engineering, Pennsylvania State University, University Park, PA, 16802, USA.
Fan ZhaoMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Huiyin TuDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Han-Jun WangDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Lie GaoDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yunfan KongMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bo LiuMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mena A KrishnanMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Tianshu PanMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Zhi HeMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yiran LiMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yang WuMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Dominick J DiMaioDepartment of Pathology and Microbiology University of Nebraska Medical Center Omaha, NE, 68198, USA.
Yu-Long LiDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Paul T DeeganDepartment of Biomechanics, University of Nebraska Omaha, Omaha, NE, 68182, USA.
Anastasia DesyatovaDepartment of Biomechanics, University of Nebraska Omaha, Omaha, NE, 68182, USA.
Alexey KamenskiyDepartment of Biomechanics, University of Nebraska Omaha, Omaha, NE, 68182, USA.
Siwei ZhaoMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bin DuanMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Funding

Tissue Analysis Core (TAC)P20GM152301 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI Alexey Kamenskiy · 2024 to 2026
$8.8M
Development of optoelectronically active nerve adhesive for accelerating peripheral nerve repairR21NS131938 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, YU, CUNJIANG · 2023 to 2023
$437k
A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve InjuriesR21AR078439 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, ZHAO, SIWEI · 2021 to 2022
$378k
NIAMS NIH HHS R21 AR078439NIGMS NIH HHS P20 GM152301NINDS NIH HHS R21 NS131938
6 · The paper itself

Abstract

Electrical stimulation (EStim) has been used to exercise denervated muscle pending nerve regeneration, to prevent muscle atrophy. However, higher EStim intensity is required to achieve maximal therapeutic efficacy, which is challenging because conventional electrodes generate heat and alter pH, potentially causing tissue damage. Here, we developed and utilized a novel hydrogel ionic circuit (HIC)-based EStim system that is ionically conductive and prevents tissue damage. This HIC was safely used to deliver a high EStim intensity of 32 mA both

Indexed as

Denervated muscleElectrical stimulationHydrogel ionic circuitMuscle atrophyNeuromuscular junctionsPeripheral nerve injury

Identifiers

PMID42729938
PMCPMC13563251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.