Evidence map›Paper›PMID 42729836›Full record

ArticleACS omega2026

A Novel Unsupervised Learning Model with Bayesian Hyperparameter Optimization for Predicting Substrates of Promiscuous Enzymes.

Rongsheng Gao, Chengye Duan, Nan Qin, Youmeng Liu, Kunyu Liu, Tatsuhisa Tsuboi, Zhen Chen

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rongsheng GaoKey Laboratory of Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Chengye DuanKey Laboratory of Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.ORCID https://orcid.org/0009-0008-2615-9817
Nan QinKey Laboratory of Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.ORCID https://orcid.org/0009-0007-5948-1493
Youmeng LiuKey Laboratory of Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Kunyu LiuKey Laboratory of Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Tatsuhisa TsuboiInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China.
Zhen ChenKey Laboratory of Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.ORCID https://orcid.org/0000-0003-3792-5544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promiscuous enzymes catalyze multiple biochemical reactions, but predicting their substrate profiles remains challenging because annotations are incomplete, reliable negative labels are scarce, and enzyme-substrate relationships are inherently multilabel. Here, we present

Identifiers

PMID42729836
PMCPMC13563996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.