Evidence map›Paper›PMID 42729830›Full record

ArticleACS omega2026

Prodrug-like Quinone Containing Two Redox-Active Centers Induces Ferroptosis in Prostate Cancer Cells with Cytotoxic Action Partially Depending on NAD(P)H Quinone Dehydrogenase 1 (NQO1).

Eleicy N Mendoza, Maria Fernanda Madrid, Pedro M S da Costa, Serena Castelli, Fabio Ciccarone, Maria R Ciriolo, Bruno C Cavalcanti, Emmanuel S Marinho, Jacilene Silva, Eveline M Bezerra and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Eleicy N MendozaDepartment of Physiology and Pharmacology, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Ceará 60430-275, Brazil.
Maria Fernanda MadridDepartment of Physiology and Pharmacology, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Ceará 60430-275, Brazil.
Pedro M S da CostaDepartment of Physiology and Pharmacology, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Ceará 60430-275, Brazil.
Serena CastelliDepartment for the Promotion of Human Science and Quality of Life, Universita Telematica San Raffaele Roma, Via di Val Cannuta 247, 00166 Rome, Italy.
Fabio CiccaroneDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Maria R CirioloDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Bruno C CavalcantiDepartment of Physiology and Pharmacology, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Ceará 60430-275, Brazil.
Emmanuel S MarinhoLaboratory of Bioprospecting and Monitoring of Natural Resources, Center of Science and Technology, Universidade Estadual do Ceará, Fortaleza, Ceará 60714-903, Brazil.ORCID https://orcid.org/0000-0002-4774-8775
Jacilene SilvaLaboratory of Bioprospecting and Monitoring of Natural Resources, Center of Science and Technology, Universidade Estadual do Ceará, Fortaleza, Ceará 60714-903, Brazil.
Eveline M BezerraPostgraduate Program in Materials Science and Engineering, Universidade Federal Rural do Semi-Arido, Mossoró, Rio Grande do Norte 59625-900, Brazil.ORCID https://orcid.org/0000-0002-2210-0526
Roner F da CostaPostgraduate Program in Materials Science and Engineering, Universidade Federal Rural do Semi-Arido, Mossoró, Rio Grande do Norte 59625-900, Brazil.
Renata G AlmeidaDepartment of Chemistry, Institute of Exact Sciences,Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID https://orcid.org/0000-0003-2896-0487
Joyce C de OliveiraDepartment of Chemistry, Institute of Exact Sciences,Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
Francisco Washington A Barros-NepomucenoInstitute of Health Sciences, Universidade da Integração Internacional da Lusofonia Afro-Brasileira, Redenção, Ceará 62790-000, Brazil.
Manoel O de Moraes FilhoDepartment of Physiology and Pharmacology, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Ceará 60430-275, Brazil.
Eufrânio N da Silva JúniorDepartment of Chemistry, Institute of Exact Sciences,Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID https://orcid.org/0000-0003-1281-5453
Claudia PessoaDepartment of Physiology and Pharmacology, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Ceará 60430-275, Brazil.
Carlos R K PaierDepartment of Physiology and Pharmacology, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Ceará 60430-275, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naphthoquinones are redox-active compounds with antitumor potential, often linked to NQO1 overexpression in cancer cells. This study evaluated the cytotoxic activity of two synthetic 1,4-naphthoquinones, compound

Identifiers

PMID42729830
PMCPMC13564003

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.