Evidence map›Paper›PMID 42729821›Full record

SynthesisFrontiers in pharmacology2026

Efficacy and safety of modified

Bozhen Huang, Hongyi Lan, Meijiao Zhou, Shanshan Song, Manman Zhang, Luyao Wang, Min Jiang

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bozhen Huang *Department of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Hongyi Lan *Department of Cardiology, Wuxi Hospital of Traditional Chinese Medicine, Wuxi, China.
Meijiao Zhou *Department of Rheumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shanshan SongDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Manman ZhangInstitute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Luyao WangDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Min JiangDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To comprehensively evaluate the efficacy and safety of modified Methods: Randomized controlled trials (RCTs) on the treatment of postoperative depression of breast cancer patients with modified XYS were searched from eight databases. All relevant literature from the inception of each database up to 12 July 2026 were retrieved. The Cochrane risk of bias assessment tool was used to evaluate the risk of bias in all included studies. After screening and data extraction, RevMan 5.2 and Stata 12.0 were used for meta-analysis. Results: 11 RCTs were included, involving a total of 748 patients, with 374 in the treatment group and 374 in the control group. Subgroup analyses showed that modified XYS plus antidepressants (AD) was associated with a significantly greater improvement in depressive symptoms than AD alone [SMD = -0.99, 95% CI (-1.57, -0.42), Conclusion: This study indicates that modified XYS has a positive effect on the improvement of depression scale scores, neurotransmitters in patients with postoperative depression of breast cancer. However, further verification is needed through more high-quality RCTs. Systematic Review Registration: https://www.crd.york.ac.uk/prospero, identifier CRD420251035045.

Indexed as

breast cancerdepressionmeta-analysisrandomized controlled trialsystematic reviewXiaoyao-san

Identifiers

PMID42729821
PMCPMC13563646

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.