Evidence map›Paper›PMID 42729776›Full record

ReviewACS omega2026

Interfacial Engineering of Biosensors for Bloodstream Infection Diagnosis.

Heng Zhang, Mengqi Bai, Jingwen Wang, Zixuan Sun, Feiyi Zhang, Mengxiao Zhao, Jiaming Tang, Shaobo Wu, Zengkai Wang, Liu Lei

Abstract readReview
In one paragraph

Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heng ZhangSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
Mengqi BaiDepartment of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Jingwen WangSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.ORCID https://orcid.org/0009-0006-7046-5999
Zixuan SunSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.ORCID https://orcid.org/0000-0002-7789-6509
Feiyi ZhangSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
Mengxiao ZhaoSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
Jiaming TangSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.
Shaobo WuZhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, Jiangsu 212013, China.
Zengkai WangSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.ORCID https://orcid.org/0000-0002-2046-6612
Liu LeiSchool of Materials Science and Engineering, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, China.ORCID https://orcid.org/0000-0002-6265-9412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bloodstream infection (BSI) is a life-threatening systemic disease with rapid onset and high mortality, which calls for rapid and accurate pathogen detection for precision medical care. Conventional diagnostic methods, including blood culture, molecular assays, and mass spectrometry, remain limited by long turnaround time, matrix interference, high cost, or insufficient point-of-care applicability. Biosensor interface engineering provides a promising route to improve pathogen capture, antifouling capability, and signal transduction in complex blood matrices. In this review, we summarize recent advances in biosensing interfaces for BSI diagnosis from three interconnected perspectives: signal transduction strategies, biorecognition elements, and antifouling surface designs. We further discuss direct sensing of intact bacterial cells and indirect sensing of bacterial or host-response biomarkers. Finally, remaining challenges in whole-blood compatibility, device integration, standardization, and clinical validation are highlighted to guide the development of next-generation point-of-care diagnostic platforms.

Identifiers

PMID42729776
PMCPMC13563607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.