ReviewFrontiers in cell and developmental biology2026
Molecular mechanisms and translational potential of plant-derived nanovesicles in skin care and regeneration.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-derived nanovesicles (PDNVs) are emerging as a novel class of natural biomaterials with significant potential in dermatological applications, owing to their unique lipid bilayer structure, broad source availability, and low immunogenicity. This review systematically delineates the biogenesis pathways of PDNVs-including the multivesicular body (MVB) and exocyst-positive organelle (EXPO) routes-and characterizes their complex cargo, which encompasses functional proteins, regulatory microRNAs, and bioactive secondary metabolites. We critically discuss the molecular mechanisms underlying the skincare efficacy of PDNVs, emphasizing their roles in antioxidant defense via Nrf2 activation, anti-aging effects through the modulation of MMP expression and collagen synthesis, melanogenesis inhibition, and the promotion of wound healing by regulating inflammatory cytokines and the TGF-β pathway. Furthermore, the article compares PDNVs with synthetic nanocarriers and other extracellular vesicles, highlighting their superior biocompatibility and cellular uptake efficiency as natural delivery systems. Finally, we address current industrial challenges related to standardized isolation, quality control, and storage stability, and propose future perspectives on bioengineering strategies and clinical translation. This work provides a comprehensive theoretical foundation for the application of PDNVs in precision dermatology and cosmetic biotechnology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.